2-[3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-but-3-en-1-ol

Base Information

Chemical Name:2-[3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-but-3-en-1-ol
CAS No.:252006-16-9
Molecular Formula:C₃₃H₄₄O₅Si
Molecular Weight:548.795
Hs Code.:

2-[3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-but-3-en-1-ol

Synonyms:2-[3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-but-3-en-1-ol

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Chemical Property of 2-[3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-but-3-en-1-ol

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Technology Process of 2-[3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-but-3-en-1-ol

There total 7 articles about 2-[3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-but-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 252006-15-8
tert-Butyl-{(R)-2-[(4S,5S)-2-(3,4-dimethoxy-phenyl)-5-vinyl-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane

: 252006-16-9
2-[3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-but-3-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In hexane; toluene; at -35 ℃; for 1h;
DOI:10.1248/cpb.47.1288

Reference yield:

: 240821-02-7
tert-Butyl-{(R)-2-[(2S,4S,5S)-2-(3,4-dimethoxy-phenyl)-5-vinyl-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane

: 252006-16-9
2-[3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-but-3-en-1-ol

Guidance literature:: With diisobutylaluminium hydride; In toluene; at -30 ℃;
DOI:10.1055/s-1999-2730

Reference yield:

: 91751-24-5,92817-88-4,123284-89-9,112897-04-8
(R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal

: 252006-16-9
2-[3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-but-3-en-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / TiCl₄; iso-Pr₂EtN / CH₂Cl₂ / 3 h / 0 °C

2: LiBH₄ / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

3: aq. NaOH / diethyl ether

4: 99 percent / dl-camphorsulfonic acid / CH₂Cl₂ / 5 h / 20 °C

5: 93 percent / DIBAH / hexane; toluene / 1 h / -35 °C

With sodium hydroxide; lithium borohydride; camphor-10-sulfonic acid; titanium tetrachloride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; 1: Condensation / 2: Reduction / 3: Hydrolysis / 4: Substitution / 5: reductive ring opening;
DOI:10.1248/cpb.47.1288