1-<2-hydroxy-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrochloride

Base Information

• Chemical Name: 1-<2-hydroxy-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrochloride
• CAS No.: 74178-86-2
• Molecular Formula: C₂₀H₂₃N₃O₄*ClH
• Molecular Weight: 405.881

Synonyms:1-<2-hydroxy-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrochloride

Chemical Property of 1-<2-hydroxy-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrochloride

Chemical Property:

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Technology Process of 1-<2-hydroxy-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrochloride

There total 4 articles about 1-<2-hydroxy-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.9%

1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; hydrochloride (82832-84-6) → 1-<2-hydroxy-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrochloride (74178-86-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1248/cpb.30.462

Reference yield:

2-bromo-3',4'-bis(benzyloxy)acetophenone (27628-05-3) → 1-<2-hydroxy-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrochloride (74178-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 92.5 percent / Et₃N / methanol / 6 h / Ambient temperature

2: 57.9 percent / NaBH₄,HCl / methanol / 1 h / Ambient temperature

3: 94.9 percent / H₂ / Pd/C / methanol / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In methanol;

DOI:10.1248/cpb.30.462

Reference yield:

4-(2-keto-1-benzimidazolinyl)piperidine (20662-53-7) → 1-<2-hydroxy-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrochloride (74178-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 92.5 percent / Et₃N / methanol / 6 h / Ambient temperature

2: 57.9 percent / NaBH₄,HCl / methanol / 1 h / Ambient temperature

3: 94.9 percent / H₂ / Pd/C / methanol / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In methanol;

DOI:10.1248/cpb.30.462

upstream raw materials:

1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; hydrochloride

2-bromo-3',4'-bis(benzyloxy)acetophenone

4-(2-keto-1-benzimidazolinyl)piperidine

1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-oxo-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one

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