N⁶-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine 2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate>

Base Information

• Chemical Name: N⁶-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine 2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate>
• CAS No.: 112237-70-4
• Molecular Formula: C₅₁H₄₃Cl₂N₆O₁₀P
• Molecular Weight: 1001.82

Synonyms:N⁶-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine 2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate>

Chemical Property of N⁶-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine 2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate>

Chemical Property:

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Technology Process of N⁶-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine 2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate>

There total 6 articles about N⁶-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine 2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(4-nitrophenyl)ethanol (100-27-6) + Phosphoric acid (2R,3R,5S)-2-(6-benzoylamino-purin-9-yl)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester [1,2,4]triazol-1-yl ester → N6-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine 2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate> (112237-70-4)

Guidance literature:

In pyridine; at 2 ℃; for 2.5h;

DOI:10.1002/hlca.19870700808

Reference yield:

N-(9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (76902-49-3) → N6-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine 2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate> (112237-70-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / pyridine / methanol / 24 h / Ambient temperature; the more 30 min

2: pyridine / 0.5 h

3: 88 percent / pyridine / 2.5 h / 2 °C

With pyridine; In pyridine; methanol;

DOI:10.1002/hlca.19870700808

Reference yield:

(2R,3R,5S)-2-[6-(N-benzoylbenzamido)-9H-purin-9-yl]-5-[(benzoyloxy)methyl]oxolan-3-yl benzoate (66884-45-5) → N6-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine 2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate> (112237-70-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / NaOH (1N) / ethanol; pyridine / 0.75 h / Ambient temperature

2: 81 percent / pyridine / methanol / 24 h / Ambient temperature; the more 30 min

3: pyridine / 0.5 h

4: 88 percent / pyridine / 2.5 h / 2 °C

With pyridine; sodium hydroxide; In pyridine; methanol; ethanol;

DOI:10.1002/hlca.19870700808

upstream raw materials:

2-(4-nitrophenyl)ethanol

2,5-dichlorophenyl phosphorodichloridate

N-(9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

N⁶-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenosine

Downstream raw materials:

N⁶-benzoyl-3'-deoxyadenylyl-<2'-P-2-(p-nitrophenyl)ethyl)>-> 5'>-N⁶-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine

N⁶-benzoyl-3'-deoxy-5'-O-(monomethoxytrityl)adenylyl-<2'-P-(2-(p-nitrophenyl)ethyl)>-> 5'>-N⁶-benzoyl-2'-O-<(tert-butyldimethyl)silyl>-3'-deoxyadenosine

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