4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide

Base Information

Chemical Name:4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide
CAS No.:155836-50-3
Molecular Formula:C₂₇H₃₇N₃O₂
Molecular Weight:435.61
Hs Code.:

Synonyms:4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide

Suppliers and Price of 4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BW373U86
2.5mg
$ 415.00

ApexBio Technology
BW373U86
10mg
$ 465.00

Alichem
4-((R)-((2s,5r)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl)-n,n-diethylbenzamide
250mg
$ 1757.46

Alichem
4-((R)-((2s,5r)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl)-n,n-diethylbenzamide
50mg
$ 608.44

Total 1 raw suppliers

Chemical Property of 4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide

Chemical Property:

Boiling Point:579.5±50.0 °C(Predicted)
Density:1.071±0.06 g/cm3(Predicted)

Purity/Quality:

≥99% by HPLC ^*data from raw suppliers

BW373U86 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide

There total 21 articles about 4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-O-TBDMS-benzyl]-N,N-diethylbenzamide

: 155836-50-3,150428-54-9
4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 45.0%

: 156727-74-1
(+)-4-[(αR)-α-(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamide

: 155836-50-3,150428-54-9
4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide

Guidance literature:: With boron tribromide;
DOI:10.1021/jm00040a002

Reference yield: 27.0%

: 58287-77-7
N,N-diethyl-4-formylbenzamide

: 117973-14-5
3-(tert-butyldimethylsilyloxy)phenylmagnesium bromide

: 155836-78-5
(-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine

: 155836-50-3,150428-54-9
4-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide

Guidance literature:: N,N-diethyl-4-formylbenzamide; (-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine; With 1,2,3-Benzotriazole; In toluene; at 20 ℃; for 2h; Heating / reflux;

3-(tert-butyldimethylsilyloxy)phenylmagnesium bromide; In tetrahydrofuran; toluene; at 20 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran; toluene;