10-deacetyl-2-(hexahydro)baccatin III

Base Information

• Chemical Name: 10-deacetyl-2-(hexahydro)baccatin III
• CAS No.: 158660-66-3
• Molecular Formula: C₂₉H₄₂O₁₀
• Molecular Weight: 550.646
• Mol file: 158660-66-3.mol

Synonyms:10-deacetyl-2-(hexahydro)baccatin III

Chemical Property of 10-deacetyl-2-(hexahydro)baccatin III

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 10-deacetyl-2-(hexahydro)baccatin III

There total 1 articles about 10-deacetyl-2-(hexahydro)baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

10-deacetylbaccatin III (32981-86-5,172018-16-5) → 10-deacetyl-2-(hexahydro)baccatin III (158660-66-3)

Guidance literature:

With hydrogen; Rh on carbon; In methanol; at 35 ℃; for 24h; under 25857.4 Torr;

DOI:10.1021/jm00042a013

Reference yield: 74.0%

10-deacetyl-2-(hexahydro)baccatin III (158660-66-3) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → 10-deacetyl-7,10-bis<(2,2,2-trichloroethoxy)carbonyl>-2-(hexahydro)baccatin III (158660-67-4)

Guidance literature:

With pyridine; at 80 ℃; for 0.5h;

DOI:10.1021/jm00042a013

Reference yield:

10-deacetyl-2-(hexahydro)baccatin III (158660-66-3) → 3'-cyclohexyl-3'-dephenyl-2-(hexahydro)docetaxel

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / pyridine / 0.5 h / 80 °C

2: 75 percent / NaHMDS / hexane; tetrahydrofuran / 0.5 h / -30 °C

3: 45 percent / AcOH, Zn / methanol / 60 °C

With pyridine; sodium hexamethyldisilazane; acetic acid; zinc; In tetrahydrofuran; methanol; hexane;

DOI:10.1021/jm00042a013

upstream raw materials:

10-deacetylbaccatin III

Downstream raw materials:

10-deacetyl-7,10-bis<(2,2,2-trichloroethoxy)carbonyl>-2-(hexahydro)baccatin III

Refernces