(S,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide

Base Information

• Chemical Name: (S,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide
• CAS No.: 304682-55-1
• Molecular Formula: C₃₀H₄₆N₆O₇
• Molecular Weight: 602.731

Synonyms:(S,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide

Chemical Property of (S,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (S,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide

There total 4 articles about (S,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

3-dimethylamino-2,2-dimethyl-2H-azirine (54856-83-6) + (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid (304682-70-0) → (S,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide (304682-55-1) + (R,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide (304682-54-0)

Guidance literature:

In acetonitrile; at 20 ℃; for 42h;

DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield:

2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methylpropanoic acid (266338-75-4) → (S,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide (304682-55-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 15 h / 20 °C

2: 74 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 17 h / 20 °C

3: 98 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 21 h / 20 °C

4: 34 percent / acetonitrile / 42 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile; 1: Condensation / 2: Condensation / 3: Hydrolysis / 4: Addition;

DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield:

methyl 2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}ethanoate (304682-65-3) → (S,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide (304682-55-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 17 h / 20 °C

2: 98 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 21 h / 20 °C

3: 34 percent / acetonitrile / 42 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile; 1: Condensation / 2: Hydrolysis / 3: Addition;

DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

upstream raw materials:

3-dimethylamino-2,2-dimethyl-2H-azirine

(S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid

2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methylpropanoic acid

methyl 2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}ethanoate

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