(S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid
• CAS No.: 304682-70-0
• Molecular Formula: C₂₄H₃₄N₄O₇
• Molecular Weight: 490.557

Synonyms:(S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid

Chemical Property of (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid

There total 3 articles about (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate (304682-69-7) → (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid (304682-70-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 21h;

DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield:

2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methylpropanoic acid (266338-75-4) → (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid (304682-70-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 15 h / 20 °C

2: 74 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 17 h / 20 °C

3: 98 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 21 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile; 1: Condensation / 2: Condensation / 3: Hydrolysis;

DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield:

methyl 2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}ethanoate (304682-65-3) → (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid (304682-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 17 h / 20 °C

2: 98 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 21 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; water; acetonitrile; 1: Condensation / 2: Hydrolysis;

DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

upstream raw materials:

methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate

2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methylpropanoic acid

methyl 2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}ethanoate

Downstream raw materials:

(S,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide

(R,S)-2-[1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxamido]-2,N,N-trimethylpropanamide

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