2-(2-carboxy-2-(4-((triisopropylsilyloxy)methyl)phenyl)ethylcarbamoyl)benzoic acid

Base Information

Chemical Name:2-(2-carboxy-2-(4-((triisopropylsilyloxy)methyl)phenyl)ethylcarbamoyl)benzoic acid
CAS No.:1253955-10-0
Molecular Formula:C₂₇H₃₇NO₆Si
Molecular Weight:499.679
Hs Code.:

Synonyms:2-(2-carboxy-2-(4-((triisopropylsilyloxy)methyl)phenyl)ethylcarbamoyl)benzoic acid

Suppliers and Price of 2-(2-carboxy-2-(4-((triisopropylsilyloxy)methyl)phenyl)ethylcarbamoyl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-carboxy-2-(4-((triisopropylsilyloxy)methyl)phenyl)ethylcarbamoyl)benzoic acid

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 2-(2-carboxy-2-(4-((triisopropylsilyloxy)methyl)phenyl)ethylcarbamoyl)benzoic acid

There total 4 articles about 2-(2-carboxy-2-(4-((triisopropylsilyloxy)methyl)phenyl)ethylcarbamoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253955-09-7
methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanoate

: 1253955-10-0
2-(2-carboxy-2-(4-((triisopropylsilyloxy)methyl)phenyl)ethylcarbamoyl)benzoic acid

Guidance literature:: methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propanoate; With lithium hydroxide monohydrate; water; In tetrahydrofuran;

With hydrogenchloride; ammonium chloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 1253955-10-0
2-(2-carboxy-2-(4-((triisopropylsilyloxy)methyl)phenyl)ethylcarbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water

With 2,6-dimethylpyridine; lithium hydroxide monohydrate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmcl.2016.03.104

Reference yield:

: 155380-11-3
methyl 4-(hydroxymethyl)phenylacetate

: 1253955-10-0
2-(2-carboxy-2-(4-((triisopropylsilyloxy)methyl)phenyl)ethylcarbamoyl)benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine / dichloromethane

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water

With 2,6-dimethylpyridine; lithium hydroxide monohydrate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmcl.2016.03.104