4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-hydroxyethylcarbamoyl)-6-(4-chloro-phenyl)

Base Information

Chemical Name:4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-hydroxyethylcarbamoyl)-6-(4-chloro-phenyl)
CAS No.:1407830-88-9
Molecular Formula:C₂₁H₂₂ClN₅O₂
Molecular Weight:411.891
Hs Code.:

Synonyms:4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-hydroxyethylcarbamoyl)-6-(4-chloro-phenyl)

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Chemical Property of 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-hydroxyethylcarbamoyl)-6-(4-chloro-phenyl)

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Technology Process of 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-hydroxyethylcarbamoyl)-6-(4-chloro-phenyl)

There total 8 articles about 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-hydroxyethylcarbamoyl)-6-(4-chloro-phenyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1407835-45-3
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-(tert-butyldimethylsilyloxy)ethylcarbamoyl)-6-(4-chloro-phenyl)

: 1407830-88-9
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-hydroxyethylcarbamoyl)-6-(4-chloro-phenyl)

Guidance literature:: With hydrogenchloride; In ethanol; water; at 20 ℃; for 12h;

Reference yield:

: 1407830-61-8
(R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine

: 1407830-88-9
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-hydroxyethylcarbamoyl)-6-(4-chloro-phenyl)

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / 12 h / 90 °C / 760.05 Torr

2: hydrogenchloride / ethanol; water / 12 h / 20 °C

With hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; In ethanol; water;

Reference yield:

: 1407833-48-0
methyl 3-(5-bromo-2-nitrophenylamino)-2-methylpropanoate

: 1407830-88-9
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-hydroxyethylcarbamoyl)-6-(4-chloro-phenyl)

Guidance literature:: Multi-step reaction with 8 steps

1: ammonium chloride; iron / ethanol; water / 2 h / 60 °C

2: sodium / methanol / 0 - 20 °C

3: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

4: butan-1-ol / 12 h / 130 °C

5: caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 12 h / 110 °C / Inert atmosphere

6: Daicel AD-H / 38 °C / Resolution of racemate

7: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / 12 h / 90 °C / 760.05 Torr

8: hydrogenchloride / ethanol; water / 12 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; Lawessons reagent; hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; sodium; iron; ammonium chloride; caesium carbonate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; toluene; butan-1-ol;