4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-(tert-butyldimethylsilyloxy)ethylcarbamoyl)-6-(4-chloro-phenyl)

Base Information

Chemical Name:4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-(tert-butyldimethylsilyloxy)ethylcarbamoyl)-6-(4-chloro-phenyl)
CAS No.:1407835-45-3
Molecular Formula:C₂₇H₃₆ClN₅O₂Si
Molecular Weight:526.154
Hs Code.:

Synonyms:4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-(tert-butyldimethylsilyloxy)ethylcarbamoyl)-6-(4-chloro-phenyl)

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Chemical Property of 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-(tert-butyldimethylsilyloxy)ethylcarbamoyl)-6-(4-chloro-phenyl)

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Technology Process of 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-(tert-butyldimethylsilyloxy)ethylcarbamoyl)-6-(4-chloro-phenyl)

There total 8 articles about 4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-(tert-butyldimethylsilyloxy)ethylcarbamoyl)-6-(4-chloro-phenyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 201230-82-2
carbon monoxide

: 1407830-61-8
(R)-8-bromo-6-(4-chlorophenyl)-1,4-dimethyl-5,6-dihydro-4Hbenzo[b][1,2,4]triazolo[4,3-d][1,4]diazepine

: 101711-55-1
2‐((tert‐butyldimethylsilyl)oxy)ethan‐1‐amine

: 1407835-45-3
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-(tert-butyldimethylsilyloxy)ethylcarbamoyl)-6-(4-chloro-phenyl)

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; at 90 ℃; for 12h; under 760.051 Torr;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1407835-45-3
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-(tert-butyldimethylsilyloxy)ethylcarbamoyl)-6-(4-chloro-phenyl)

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

2: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / 12 h / 90 °C / 760.05 Torr

With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; In dichloromethane;

Reference yield:

: 1407833-48-0
methyl 3-(5-bromo-2-nitrophenylamino)-2-methylpropanoate

: 1407835-45-3
4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine, 5,6-dihydro-(R)-1,4-dimethyl-8-(2-(tert-butyldimethylsilyloxy)ethylcarbamoyl)-6-(4-chloro-phenyl)

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium chloride; iron / ethanol; water / 2 h / 60 °C

2: sodium / methanol / 0 - 20 °C

3: Lawessons reagent / tetrahydrofuran / 12 h / 80 °C

4: butan-1-ol / 12 h / 130 °C

5: caesium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 12 h / 110 °C / Inert atmosphere

6: Daicel AD-H / 38 °C / Resolution of racemate

7: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / 12 h / 90 °C / 760.05 Torr

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; Lawessons reagent; 1,3-bis-(diphenylphosphino)propane; sodium; iron; ammonium chloride; caesium carbonate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; toluene; butan-1-ol;