Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester

Base Information

Chemical Name:Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester
CAS No.:124662-57-3
Molecular Formula:C₂₅H₃₂O₁₀
Molecular Weight:492.523
Hs Code.:

Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester

Synonyms:Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester

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Chemical Property of Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester

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Technology Process of Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester

There total 11 articles about Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 107-30-2
chloromethyl methyl ether

: 119384-68-8
3-hydroxymethyl-2-(4-hydroxy-3-methoxyphenyl)-7-hydroxy-5-acetoxymethyl-2,3-dihydrobenzofuran

: 124662-57-3
Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1248/cpb.37.1441

Reference yield:

: 1835-11-6
4-benzyloxy-3-methoxyacetophenone

: 124662-57-3
Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / KOH / ethanol

2: 87 percent / conc. HCl / methanol; dioxane

3: 92 percent / 30percent H₂O₂, 5percent NaOH / methanol; dioxane

4: 1.) BF₃*Et₂O, 2.) NaBH₄ / 1.) benzene, 0 deg C, 2.) THF

5: 66 percent / H₂ / 10percent Pd-C / methanol

6: BF₃-Et₂O / 5 °C

7: 66 percent / (i-Pr)2NEt / CH₂Cl₂

With hydrogenchloride; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1039/c39880000749

Reference yield:

: 119384-66-6
1-(4-benzyloxy-3-methoxyphenyl)-3-(2,3-dibenzyloxy-5-formylphenyl)-2,3-epoxy-1-propanone

: 124662-57-3
Acetic acid (2S,3R)-7-methoxymethoxy-2-(3-methoxy-4-methoxymethoxy-phenyl)-3-methoxymethoxymethyl-2,3-dihydro-benzofuran-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) BF₃*Et₂O, 2.) NaBH₄ / 1.) benzene, 0 deg C, 2.) THF

2: 66 percent / H₂ / 10percent Pd-C / methanol

3: BF₃-Et₂O / 5 °C

4: 66 percent / (i-Pr)2NEt / CH₂Cl₂

With sodium tetrahydroborate; boron trifluoride diethyl etherate; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1039/c39880000749