2,2,2-trifluoro-N-(4-methoxyphenyl)-N'-(2-(phenylethynyl)phenyl)acetimidamide

Base Information

• Chemical Name: 2,2,2-trifluoro-N-(4-methoxyphenyl)-N'-(2-(phenylethynyl)phenyl)acetimidamide
• CAS No.: 1353882-71-9
• Molecular Formula: C₂₃H₁₇F₃N₂O
• Molecular Weight: 394.396

Synonyms:2,2,2-trifluoro-N-(4-methoxyphenyl)-N'-(2-(phenylethynyl)phenyl)acetimidamide

Chemical Property of 2,2,2-trifluoro-N-(4-methoxyphenyl)-N'-(2-(phenylethynyl)phenyl)acetimidamide

Chemical Property:

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Technology Process of 2,2,2-trifluoro-N-(4-methoxyphenyl)-N'-(2-(phenylethynyl)phenyl)acetimidamide

There total 2 articles about 2,2,2-trifluoro-N-(4-methoxyphenyl)-N'-(2-(phenylethynyl)phenyl)acetimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(ortho-phenylethynyl)phenyl trifluoroacetimidoyl chloride (154374-85-3) + 4-methoxy-aniline (104-94-9) → 2,2,2-trifluoro-N-(4-methoxyphenyl)-N'-(2-(phenylethynyl)phenyl)acetimidamide (1353882-71-9)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1039/c1ob06528a

Reference yield:

2-phenylethynylaniline (13141-38-3) → 2,2,2-trifluoro-N-(4-methoxyphenyl)-N'-(2-(phenylethynyl)phenyl)acetimidamide (1353882-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrachloromethane; triethylamine; triphenylphosphine / 80 °C

2: triethylamine / N,N-dimethyl-formamide / 2 h / 80 °C

With tetrachloromethane; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide;

DOI:10.1039/c1ob06528a

Reference yield: 89.0%

2,2,2-trifluoro-N-(4-methoxyphenyl)-N'-(2-(phenylethynyl)phenyl)acetimidamide (1353882-71-9) → (Z)-4-methoxy-N-(2,2,2-trifluoro-1-(2-phenyl-1H-indol-1-yl)ethylidene)aniline (1353882-94-6)

Guidance literature:

With sodium tetrachloroaurate(III) dihyrate; In toluene; at 20 ℃; for 1h;

DOI:10.1039/c1ob06528a

upstream raw materials:

N-(ortho-phenylethynyl)phenyl trifluoroacetimidoyl chloride

4-methoxy-aniline

2-phenylethynylaniline

Downstream raw materials:

(E)-4-benzylidene-3-(4-methoxyphenyl)-2-(trifluoromethyl)-3,4-dihydroquinazoline

(Z)-4-methoxy-N-(2,2,2-trifluoro-1-(2-phenyl-1H-indol-1-yl)ethylidene)aniline

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