1,1-dimethylethyl (1S,4S)-5-(3-methyl-N-{[(phenylmethyl)oxy]carbonyl}l-L-valyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl (1S,4S)-5-(3-methyl-N-{[(phenylmethyl)oxy]carbonyl}l-L-valyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate
CAS No.:1186643-86-6
Molecular Formula:C₂₄H₃₅N₃O₅
Molecular Weight:445.559
Hs Code.:

Synonyms:1,1-dimethylethyl (1S,4S)-5-(3-methyl-N-{[(phenylmethyl)oxy]carbonyl}l-L-valyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

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Chemical Property of 1,1-dimethylethyl (1S,4S)-5-(3-methyl-N-{[(phenylmethyl)oxy]carbonyl}l-L-valyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

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Technology Process of 1,1-dimethylethyl (1S,4S)-5-(3-methyl-N-{[(phenylmethyl)oxy]carbonyl}l-L-valyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

There total 1 articles about 1,1-dimethylethyl (1S,4S)-5-(3-methyl-N-{[(phenylmethyl)oxy]carbonyl}l-L-valyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62965-10-0
(S)-N-carbobenzoxy-tert-butylleucine

: 113451-59-5,174823-32-6
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

: 1186643-86-6
1,1-dimethylethyl (1S,4S)-5-(3-methyl-N-{[(phenylmethyl)oxy]carbonyl}l-L-valyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h; Product distribution / selectivity;

Reference yield:

: 1186643-86-6
1,1-dimethylethyl (1S,4S)-5-(3-methyl-N-{[(phenylmethyl)oxy]carbonyl}l-L-valyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

: 1206621-25-1
phenylmethyl {(1S)-1-[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-ylcarbonyl]-2,2-dimethylpropyl}carbamate

Guidance literature:: 1,1-dimethylethyl (1S,4S)-5-(3-methyl-N-{[(phenylmethyl)oxy]carbonyl}l-L-valyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With sodium hydroxide; In dichloromethane;

Reference yield:

: 1186643-86-6
1,1-dimethylethyl (1S,4S)-5-(3-methyl-N-{[(phenylmethyl)oxy]carbonyl}l-L-valyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

: N-((1S)-1-{[(1S,4S)-5-({4-[(2,5-dichlorophenyl)sulfonyl]-3-morpholinyl}carbonyl)-2,5-diazabicyclo[2.2.1]hept-2-yl]carbonyl}-2,2-dimethylpropyl)-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol; ammonium formate / palladium 10% on activated carbon / ethanol / 20 °C

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

5: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With 4-methyl-morpholine; ethanol; ammonium formate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide;