{4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}methylamine

Base Information

Chemical Name:{4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}methylamine
CAS No.:1208069-63-9
Molecular Formula:C₂₆H₂₉N₇
Molecular Weight:439.563
Hs Code.:

Synonyms:{4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}methylamine

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Chemical Property of {4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}methylamine

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Technology Process of {4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}methylamine

There total 7 articles about {4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1208069-62-8
[4-(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl]methylamine

: 86732-22-1
2-benzyloctahydropyrrolo[3,4-c]pyrrole

: 1208069-63-9
{4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}methylamine

Guidance literature:: [4-(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl]methylamine; 2-benzyloctahydropyrrolo[3,4-c]pyrrole; In pentan-1-ol; at 150 ℃; for 40h;

With hydrogenchloride; In pentan-1-ol; water;

With ammonia; silica gel; In methanol; dichloromethane; water;

Reference yield:

: 207799-10-8
(4-bromopyridin-2-yl)-carbamic acid tert-butyl ester

: 1208069-63-9
{4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}methylamine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

2: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

4: trifluoroacetic acid / chloroform / 18 h / 20 °C

5: pentan-1-ol / 40 h / 150 °C

With potassium acetate; sodium hydride; caesium carbonate; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; pentan-1-ol; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1095708-32-9
N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]carbamic acid 1,1-dimethylethyl ester

: 1208069-63-9
{4-[6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-methylimidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}methylamine

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

3: trifluoroacetic acid / chloroform / 18 h / 20 °C

4: pentan-1-ol / 40 h / 150 °C

With sodium hydride; caesium carbonate; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; pentan-1-ol; chloroform; water; N,N-dimethyl-formamide; mineral oil;