4-{3-[3-fluoro-4-(3-oxazol-2-yl-propyl)-phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl}-2-trifluoromethyl-benzonitrile

Base Information

Chemical Name:4-{3-[3-fluoro-4-(3-oxazol-2-yl-propyl)-phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl}-2-trifluoromethyl-benzonitrile
CAS No.:1398045-95-8
Molecular Formula:C₂₅H₂₀F₄N₄O₂S
Molecular Weight:516.519
Hs Code.:

Synonyms:4-{3-[3-fluoro-4-(3-oxazol-2-yl-propyl)-phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl}-2-trifluoromethyl-benzonitrile

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Chemical Property of 4-{3-[3-fluoro-4-(3-oxazol-2-yl-propyl)-phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl}-2-trifluoromethyl-benzonitrile

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Technology Process of 4-{3-[3-fluoro-4-(3-oxazol-2-yl-propyl)-phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl}-2-trifluoromethyl-benzonitrile

There total 4 articles about 4-{3-[3-fluoro-4-(3-oxazol-2-yl-propyl)-phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl}-2-trifluoromethyl-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398048-25-3
C₁₆H₁₈FN₃O

: 1398045-95-8
4-{3-[3-fluoro-4-(3-oxazol-2-yl-propyl)-phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl}-2-trifluoromethyl-benzonitrile

Guidance literature:: C₁₆H₁₈FN₃O; 4-isothiocyanato 2-(trifluoromethyl)benzonitrile; In N,N-dimethyl-formamide; at 20 ℃;

With hydrogenchloride; methanol; In N,N-dimethyl-formamide; for 2h; Reflux;

Reference yield:

: 188975-47-5
dimethyl 2-(2-fluoro-4-nitrophenyl)malonate

: 1398045-95-8
4-{3-[3-fluoro-4-(3-oxazol-2-yl-propyl)-phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl}-2-trifluoromethyl-benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / methanol / 20 °C / Inert atmosphere

2.1: water; sodium chloride / dimethyl sulfoxide / 24 h / 155 °C / Inert atmosphere

3.1: ammonium hydroxide; methanol / 48 h / 20 °C

4.1: polyphosphoric acid / 3 h / 160 °C

5.1: ammonium chloride; iron / water; methanol / 2 h / 90 °C / Inert atmosphere

6.1: zinc(II) chloride / 1,4-dioxane / 3 h / 20 °C

7.1: N,N-dimethyl-formamide / 20 °C

7.2: 2 h / Reflux

With methanol; ammonium hydroxide; water; sodium methylate; iron; ammonium chloride; sodium chloride; zinc(II) chloride; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1146975-15-6
Trimethyl 1-(2-fluoro-4-nitrophenyl)propane-1,1,3-tricarboxylate

: 1398045-95-8
4-{3-[3-fluoro-4-(3-oxazol-2-yl-propyl)-phenyl]-4,4-dimethyl-5-oxo-2-thioxo-imidazolidin-1-yl}-2-trifluoromethyl-benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; sodium chloride / dimethyl sulfoxide / 24 h / 155 °C / Inert atmosphere

2.1: ammonium hydroxide; methanol / 48 h / 20 °C

3.1: polyphosphoric acid / 3 h / 160 °C

4.1: ammonium chloride; iron / water; methanol / 2 h / 90 °C / Inert atmosphere

5.1: zinc(II) chloride / 1,4-dioxane / 3 h / 20 °C

6.1: N,N-dimethyl-formamide / 20 °C

6.2: 2 h / Reflux

With methanol; ammonium hydroxide; water; iron; ammonium chloride; sodium chloride; zinc(II) chloride; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;