4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine

Base Information

Chemical Name:4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine
CAS No.:1588945-01-0
Molecular Formula:C₁₇H₂₄FNO₃S
Molecular Weight:341.447
Hs Code.:

Synonyms:4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine

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Chemical Property of 4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine

Chemical Property:

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Technology Process of 4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine

There total 6 articles about 4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1588945-00-9
benzyl 4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate

: 1588945-01-0
4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 1h; under 760.051 Torr;

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 1588945-01-0
4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethyl sulfoxide / 20 °C / Microwave irradiation

2.1: water; iron; acetic acid / 2 h / 20 °C

3.1: water; sulfuric acid; sodium nitrite / tetrahydrofuran / 1 h / 0 °C

3.2: 0.25 h / 0 °C

4.1: Oxone / water / 2 h / 20 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

6.1: hydrogen; palladium on activated charcoal / methanol / 1 h / 20 °C / 760.05 Torr

With Oxone; di-isopropyl azodicarboxylate; sulfuric acid; palladium on activated charcoal; water; hydrogen; iron; acetic acid; triphenylphosphine; sodium nitrite; In tetrahydrofuran; methanol; water; dimethyl sulfoxide;

Reference yield:

: 13333-79-4
3-fluoro-4-(methylthio)phenol

: 1588945-01-0
4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: Oxone / water / 2 h / 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3: hydrogen; palladium on activated charcoal / methanol / 1 h / 20 °C / 760.05 Torr

With Oxone; di-isopropyl azodicarboxylate; palladium on activated charcoal; hydrogen; triphenylphosphine; In tetrahydrofuran; methanol; water;