3-FLUORO-4-METHYLTHIOPHENOL

Base Information

• Chemical Name: 3-FLUORO-4-METHYLTHIOPHENOL
• CAS No.: 13333-79-4
• Molecular Formula: C7H7FOS
• Molecular Weight: 158.196
• Hs Code.: 2930909090
• Mol file: 13333-79-4.mol

Synonyms:3-Fluoro-4-(methylsulfanyl)phenol;3-fluoro-4-(methylthio)phenol;3-fluoro-4-methanesulfanylphenol;

Chemical Property of 3-FLUORO-4-METHYLTHIOPHENOL

Chemical Property:

• Boiling Point: 78°C 9mm
• PSA: 45.53000
• LogP: 2.25320

Purity/Quality:

99.3% ^*data from raw suppliers

3-Fluoro-4-(methylthio)phenol 97% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUORO-4-METHYLTHIOPHENOL

There total 2 articles about 3-FLUORO-4-METHYLTHIOPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

3-fluoro-4-(methylthio)benzeneamine (20901-69-3) → 3-fluoro-4-(methylthio)phenol (13333-79-4)

Guidance literature:

3-fluoro-4-(methylthio)benzeneamine; With sulfuric acid; sodium nitrite; In tetrahydrofuran; water; at 0 ℃; for 2h;

With copper(I) oxide; copper(II) nitrate; In tetrahydrofuran; water; for 0.25h;

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → 3-fluoro-4-(methylthio)phenol (13333-79-4) + 3-chloro-4-methylsulfanyl-phenol (13560-43-5)

Guidance literature:

Reference yield: 78.0%

3-fluoro-4-(methylthio)phenol (13333-79-4) → 3-fluoro-4-(methanesulfonyl)phenol (859538-50-4)

Guidance literature:

With Oxone; In tetrahydrofuran; water; at 20 ℃; for 1h;

upstream raw materials:

3,4-difluoronitrobenzene

3-fluoro-4-(methylthio)benzeneamine

Downstream raw materials:

3-fluoro-4-(methanesulfonyl)phenol

N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine

N-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)-1-(3-isopropyl-1,2,4-oxadiazol-5-yl)-N-methylpiperidine-4-amine trifluoroacetate

benzyl 4-((1S,2S)-2-(2-(3-fluoro-4-(methylsulfonyl)phenoxy)ethyl)cyclopropyl)piperidine-1-carboxylate

Refernces

• 1、 -. "SUBSTITUTED CYCLOPROPYL COMPOUNDS". Page/Page column 51. . Retrieved 2014/04/17.
• 2、 -. "GPR119 Receptor Agonists". Page/Page column 19. . Retrieved 2009/12/05.