(S)-2-methoxy-1-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)-2-oxoethyl benzoate

Base Information

Chemical Name:(S)-2-methoxy-1-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)-2-oxoethyl benzoate
CAS No.:250378-78-0
Molecular Formula:C₂₀H₂₆O₆S₂
Molecular Weight:426.555
Hs Code.:

Synonyms:(S)-2-methoxy-1-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)-2-oxoethyl benzoate

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Chemical Property of (S)-2-methoxy-1-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)-2-oxoethyl benzoate

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Technology Process of (S)-2-methoxy-1-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)-2-oxoethyl benzoate

There total 4 articles about (S)-2-methoxy-1-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)-2-oxoethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 250378-77-9
methyl (S)-2-hydroxy-2-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)acetate

: 98-88-4
benzoyl chloride

: 250378-78-0
(S)-2-methoxy-1-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)-2-oxoethyl benzoate

Guidance literature:: With pyridine; dmap; at 20 ℃; for 13h;
DOI:10.1021/ol990936g

Reference yield:

: 1336892-19-3
C₁₃H₂₄O₃S₂

: 250378-78-0
(S)-2-methoxy-1-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)-2-oxoethyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; zinc(II) chloride / tetrahydrofuran / -78 - -40 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: dmap / pyridine / Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; zinc(II) chloride; In tetrahydrofuran; pyridine;
DOI:10.1021/ja207331m

Reference yield:

: 250378-76-8
tert-Butyl syn-(4S,5R)-5-hydroxy-4-methyl-3-oxohexanoate

: 250378-78-0
(S)-2-methoxy-1-((7R,9R,10S)-7-methoxy-9,10-dimethyl-8-oxa-1,4-dithiaspiro[4.5]decan-7-yl)-2-oxoethyl benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / -40 °C / Inert atmosphere

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; zinc(II) chloride / tetrahydrofuran / -78 - -40 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: dmap / pyridine / Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; boron trifluoride diethyl etherate; zinc(II) chloride; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1021/ja207331m