7-methoxy-8-{(1-(3-(4-((E)-3-(5-chloro-2-hydroxyphenyl)-3-oxoprop-1-enyl)-2-methoxyphenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

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Chemical Name:7-methoxy-8-{(1-(3-(4-((E)-3-(5-chloro-2-hydroxyphenyl)-3-oxoprop-1-enyl)-2-methoxyphenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one
CAS No.:1335131-03-7
Molecular Formula:C₃₅H₃₄ClN₅O₇
Molecular Weight:672.137
Hs Code.:

7-methoxy-8-{(1-(3-(4-((E)-3-(5-chloro-2-hydroxyphenyl)-3-oxoprop-1-enyl)-2-methoxyphenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Synonyms:7-methoxy-8-{(1-(3-(4-((E)-3-(5-chloro-2-hydroxyphenyl)-3-oxoprop-1-enyl)-2-methoxyphenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

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Chemical Property of 7-methoxy-8-{(1-(3-(4-((E)-3-(5-chloro-2-hydroxyphenyl)-3-oxoprop-1-enyl)-2-methoxyphenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

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Technology Process of 7-methoxy-8-{(1-(3-(4-((E)-3-(5-chloro-2-hydroxyphenyl)-3-oxoprop-1-enyl)-2-methoxyphenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

There total 9 articles about 7-methoxy-8-{(1-(3-(4-((E)-3-(5-chloro-2-hydroxyphenyl)-3-oxoprop-1-enyl)-2-methoxyphenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₉H₄₆ClN₅O₇S₂

: 1335131-03-7
7-methoxy-8-{(1-(3-(4-((E)-3-(5-chloro-2-hydroxyphenyl)-3-oxoprop-1-enyl)-2-methoxyphenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Guidance literature:: With calcium carbonate; mercury dichloride; In water; acetonitrile; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2011.05.050

Reference yield:

: 1037070-06-6
(2S)-N-[5-methoxy-4-(2-propynyloxy)-2-nitrobenzoyl]-pyrrolidine-2-carboxaldehyde diethyl-dithioacetal

: 1335131-03-7
7-methoxy-8-{(1-(3-(4-((E)-3-(5-chloro-2-hydroxyphenyl)-3-oxoprop-1-enyl)-2-methoxyphenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 12 h / 20 °C

2.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

2.2: pH 8

3.1: calcium carbonate; mercury dichloride / water; acetonitrile / 12 h / 20 °C

With copper(ll) sulfate pentahydrate; tin(II) chloride dihdyrate; sodium L-ascorbate; calcium carbonate; mercury dichloride; In methanol; water; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2011.05.050

Reference yield:

: 1335130-73-8
4-(3-azidopropyloxy)-3-methoxybenzaldehyde

: 1335131-03-7
7-methoxy-8-{(1-(3-(4-((E)-3-(5-chloro-2-hydroxyphenyl)-3-oxoprop-1-enyl)-2-methoxyphenoxy)propyl)-1H-1,2,3-triazol-4-yl)methoxy}-(11aS)-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / methanol; water / 12 h / 20 °C

1.2: pH 1

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 12 h / 20 °C

3.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux

3.2: pH 8

4.1: calcium carbonate; mercury dichloride / water; acetonitrile / 12 h / 20 °C

With copper(ll) sulfate pentahydrate; tin(II) chloride dihdyrate; sodium L-ascorbate; calcium carbonate; mercury dichloride; potassium hydroxide; In methanol; water; acetonitrile; tert-butyl alcohol; 1.1: Aldol condensation;
DOI:10.1016/j.ejmech.2011.05.050