2-bromo-N-(3-{(1E)-3-[(4-methylbenzyl)amino]-3-oxoprop-1-en-1-yl}phenyl)acrylamide

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Chemical Name:2-bromo-N-(3-{(1E)-3-[(4-methylbenzyl)amino]-3-oxoprop-1-en-1-yl}phenyl)acrylamide
CAS No.:1615697-28-3
Molecular Formula:C₂₀H₁₉BrN₂O₂
Molecular Weight:399.287
Hs Code.:

Synonyms:2-bromo-N-(3-{(1E)-3-[(4-methylbenzyl)amino]-3-oxoprop-1-en-1-yl}phenyl)acrylamide

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Chemical Property of 2-bromo-N-(3-{(1E)-3-[(4-methylbenzyl)amino]-3-oxoprop-1-en-1-yl}phenyl)acrylamide

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Technology Process of 2-bromo-N-(3-{(1E)-3-[(4-methylbenzyl)amino]-3-oxoprop-1-en-1-yl}phenyl)acrylamide

There total 4 articles about 2-bromo-N-(3-{(1E)-3-[(4-methylbenzyl)amino]-3-oxoprop-1-en-1-yl}phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 10443-65-9
2-bromo-2-propenoic acid

: 1175641-90-3
(2E)-3-(3-aminophenyl)-N-(4-methylbenzyl)acrylamide

: 1615697-28-3
2-bromo-N-(3-{(1E)-3-[(4-methylbenzyl)amino]-3-oxoprop-1-en-1-yl}phenyl)acrylamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.05.028

Reference yield:

: 104-84-7
para-methylbenzylamine

: 1615697-28-3
2-bromo-N-(3-{(1E)-3-[(4-methylbenzyl)amino]-3-oxoprop-1-en-1-yl}phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate; triethylamine / chloroform / 0.17 h / 0 °C / Inert atmosphere

1.2: 0.5 h / 0 °C / Inert atmosphere

2.1: tin(II) chloride dihdyrate / ethanol / 1.5 h / Inert atmosphere; Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.05.028

Reference yield:

: 555-68-0,1772-76-5
(E)-3-Nitrocinnamic acid

: 1615697-28-3
2-bromo-N-(3-{(1E)-3-[(4-methylbenzyl)amino]-3-oxoprop-1-en-1-yl}phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate; triethylamine / chloroform / 0.17 h / 0 °C / Inert atmosphere

1.2: 0.5 h / 0 °C / Inert atmosphere

2.1: tin(II) chloride dihdyrate / ethanol / 1.5 h / Inert atmosphere; Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

With tin(II) chloride dihdyrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.05.028