(1R,2R,6R)-6-Isopropyl-3-methyl-2-phenylsulfanylmethyl-cyclohex-3-enecarboxylic acid

Base Information

Chemical Name:(1R,2R,6R)-6-Isopropyl-3-methyl-2-phenylsulfanylmethyl-cyclohex-3-enecarboxylic acid
CAS No.:291520-42-8
Molecular Formula:C₁₈H₂₄O₂S
Molecular Weight:304.453
Hs Code.:

Synonyms:(1R,2R,6R)-6-Isopropyl-3-methyl-2-phenylsulfanylmethyl-cyclohex-3-enecarboxylic acid

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Chemical Property of (1R,2R,6R)-6-Isopropyl-3-methyl-2-phenylsulfanylmethyl-cyclohex-3-enecarboxylic acid

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Technology Process of (1R,2R,6R)-6-Isopropyl-3-methyl-2-phenylsulfanylmethyl-cyclohex-3-enecarboxylic acid

There total 7 articles about (1R,2R,6R)-6-Isopropyl-3-methyl-2-phenylsulfanylmethyl-cyclohex-3-enecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 2973-86-6
lithium thiophenoxide

: 291520-41-7
(3aR,7R,7aR)-7-Isopropyl-4-methyl-3a,6,7,7a-tetrahydro-3H-isobenzofuran-1-one

: 291520-42-8
(1R,2R,6R)-6-Isopropyl-3-methyl-2-phenylsulfanylmethyl-cyclohex-3-enecarboxylic acid

Guidance literature:: In N,N-dimethyl-formamide; at 110 ℃; for 4h;
DOI:10.1016/S0040-4020(00)00309-4

Reference yield:

: 2244-16-8,6485-40-1
(S)-p-mentha-6,8-dien-2-one

: 291520-42-8
(1R,2R,6R)-6-Isopropyl-3-methyl-2-phenylsulfanylmethyl-cyclohex-3-enecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / H₂; (PPh₃)3RhCl / benzene

2: 61 percent / TiCl₄; DIPEA / CH₂Cl₂ / -78 - 0 °C

3: 71 percent / tetrahydrofuran / 20 h / Heating

4: tetrahydrofuran / 20 h / 45 °C

5: 10.40 g / H₂O₂; NaOH / tetrahydrofuran; H₂O / 1.25 h / 0 - 20 °C

6: 73 percent / Jones reagent / acetone / 11 h

7: 89 percent / dimethylformamide / 4 h / 110 °C

With sodium hydroxide; Wilkinson's catalyst; jones reagent; hydrogen; dihydrogen peroxide; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene; 1: Catalytic hydrogenation / 2: Alkylation / 3: methenylation / 4: Addition / 5: Oxidation / 6: Oxidation / 7: Ring cleavage;
DOI:10.1016/S0040-4020(00)00309-4

Reference yield:

: 499-71-8
carvotanacetone

: 291520-42-8
(1R,2R,6R)-6-Isopropyl-3-methyl-2-phenylsulfanylmethyl-cyclohex-3-enecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 61 percent / TiCl₄; DIPEA / CH₂Cl₂ / -78 - 0 °C

2: 71 percent / tetrahydrofuran / 20 h / Heating

3: tetrahydrofuran / 20 h / 45 °C

4: 10.40 g / H₂O₂; NaOH / tetrahydrofuran; H₂O / 1.25 h / 0 - 20 °C

5: 73 percent / Jones reagent / acetone / 11 h

6: 89 percent / dimethylformamide / 4 h / 110 °C

With sodium hydroxide; jones reagent; dihydrogen peroxide; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; 1: Alkylation / 2: methenylation / 3: Addition / 4: Oxidation / 5: Oxidation / 6: Ring cleavage;
DOI:10.1016/S0040-4020(00)00309-4