BENZYL CIS-(2-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE

Base Information

• Chemical Name: BENZYL CIS-(2-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE
• CAS No.: 213672-66-3
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 213672-66-3.mol

Synonyms:Carbamicacid, [(1R,2S)-2-(hydroxymethyl)cyclohexyl]-, phenylmethyl ester, rel- (9CI)

Chemical Property of BENZYL CIS-(2-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE

Chemical Property:

• Vapor Pressure: 1.99E-08mmHg at 25°C
• Refractive Index: 1.554
• Boiling Point: 437.5°C at 760 mmHg
• Flash Point: 218.4°C
• PSA: 58.56000
• Density: 1.15g/cm³
• LogP: 2.85480

Purity/Quality:

98%Min ^*data from raw suppliers

Benzyl cis-(2-hydroxymethyl)cyclohexylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZYL CIS-(2-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE

There total 27 articles about BENZYL CIS-(2-HYDROXYMETHYL)CYCLOHEXYLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-(1R,2R)-1-amino-2-hydroxymethyl-cyclohexane (R,R) amino alcohol + benzyl chloroformate (501-53-1,94274-21-2) → trans-(1R,2R)-1-(benzyloxycarbonylamino)-2-hydroxymethyl-cyclohexane (213672-84-5,213672-66-3,213672-68-5)

Guidance literature:

With sodium carbonate; In dichloromethane;

Reference yield:

(1R,2R)-(2-Amino-cyclohexyl)-methanol (89854-92-2) + benzyl chloroformate (501-53-1,94274-21-2) → Benzyl N-hydroxycarbamate (3426-71-9) + (1R,2R)-(2-Hydroxymethyl-cyclohexyl)-carbamic Acid Benzyl Ester (213672-66-3,213672-68-5)

Guidance literature:

With sodium carbonate; In dichloromethane;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + (+/-)-cis-2-hydroxymethyl-1-cyclohexylamine hydrochloride → cis-(+/-)-benzyl[2-(hydroxymethyl)cyclohexyl]carbamate (213672-66-3,213672-68-5)

Guidance literature:

With sodium carbonate; In dichloromethane; at 20 ℃;

DOI:10.1021/jm049530m

upstream raw materials:

trans-2-hydroxymethylcyclohexylamine

benzyl chloroformate

cis-2-hydroxymethylcyclohexylamine

cis-(+/-)-benzyl[2-(hydroxymethyl)cyclohexyl]carbamate

Downstream raw materials:

((1S,2R)-2-Hydroxymethyl-cyclohexyl)-carbamic acid benzyl ester

trans-(1R,2R)-1-(benzyloxycarbonylamino)-2-hydroxymethyl-cyclohexane

N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-N'-((1R,2S)-2-{[3(S)-(4-fluorobenzyl)piperidinyl]methyl}cyclohexyl)urea

N-((1R,2S)-2-{[tert-butoxycarbonyl[3-(4-fluorophenyl)propyl]amino]methyl}cyclohexyl)-N'-[3-(1-methyl-1H-tetrazol-5-yl)phenyl]urea

Refernces

• 1、 Yue, Tai-Yuen,McLeod, Douglas D.,Albertson, Kevin B.,Beck, Steven R.,Deerberg, Joerg,Fortunak, Joseph M.,Nugent, William A.,Radesca, Lilian A.,Tang, Liya,Xiang, Cathie Dong. "Stereoselective process for a CCR3 antagonist". . p. 262 - 271. Retrieved 2012/12/22.
• 2、 -. "N-UREIDOALKYL-AMINO COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY". Page/Page column 126-127. . Retrieved 2008/06/13.