methyl 1-[2-bromo-4-(1-methoxy-1-oxopropan-2-yl)-benzyl]-2-oxocyclopentanecarboxylate

Base Information

Chemical Name:methyl 1-[2-bromo-4-(1-methoxy-1-oxopropan-2-yl)-benzyl]-2-oxocyclopentanecarboxylate
CAS No.:1313591-81-9
Molecular Formula:C₁₈H₂₁BrO₅
Molecular Weight:397.266
Hs Code.:

Synonyms:methyl 1-[2-bromo-4-(1-methoxy-1-oxopropan-2-yl)-benzyl]-2-oxocyclopentanecarboxylate

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Chemical Property of methyl 1-[2-bromo-4-(1-methoxy-1-oxopropan-2-yl)-benzyl]-2-oxocyclopentanecarboxylate

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Technology Process of methyl 1-[2-bromo-4-(1-methoxy-1-oxopropan-2-yl)-benzyl]-2-oxocyclopentanecarboxylate

There total 4 articles about methyl 1-[2-bromo-4-(1-methoxy-1-oxopropan-2-yl)-benzyl]-2-oxocyclopentanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1313591-80-8
methyl 2-[3-bromo-4-(chloromethyl)phenyl]propanoate

: 10472-24-9,265317-94-0
methyl 2-oxocyclopentane-1-carboxylate

: 1313591-81-9
methyl 1-[2-bromo-4-(1-methoxy-1-oxopropan-2-yl)-benzyl]-2-oxocyclopentanecarboxylate

Guidance literature:: methyl 2-oxocyclopentane-1-carboxylate; With potassium carbonate; In acetone; at 20 ℃; for 0.5h;

methyl 2-[3-bromo-4-(chloromethyl)phenyl]propanoate; In acetone; for 12h; Reflux;
DOI:10.1016/j.bmc.2011.04.050

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1313591-81-9
methyl 1-[2-bromo-4-(1-methoxy-1-oxopropan-2-yl)-benzyl]-2-oxocyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 3 h / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.5 h / -78 °C / Inert atmosphere

2.2: 5 h / -78 - -40 °C

3.1: 1,3-DIOXOLANE; aluminum (III) chloride; tin(IV) chloride / dichloromethane / 20 h / 20 °C

4.1: potassium carbonate / acetone / 0.5 h / 20 °C

4.2: 12 h / Reflux

With 1,3-DIOXOLANE; hydrogenchloride; aluminum (III) chloride; tin(IV) chloride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; water; acetone; 3.1: Friedel Crafts alkylation;
DOI:10.1016/j.bmc.2011.04.050

Reference yield:

: 80622-53-3
methyl 2-(3-bromophenyl)propanoate

: 1313591-81-9
methyl 1-[2-bromo-4-(1-methoxy-1-oxopropan-2-yl)-benzyl]-2-oxocyclopentanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,3-DIOXOLANE; aluminum (III) chloride; tin(IV) chloride / dichloromethane / 20 h / 20 °C

2.1: potassium carbonate / acetone / 0.5 h / 20 °C

2.2: 12 h / Reflux

With 1,3-DIOXOLANE; aluminum (III) chloride; tin(IV) chloride; potassium carbonate; In dichloromethane; acetone; 1.1: Friedel Crafts alkylation;
DOI:10.1016/j.bmc.2011.04.050