80622-53-3Relevant articles and documents
Pyridineacetamide derivative serving as CDK inhibitor, and preparation method and application thereof
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, (2021/07/28)
The invention belongs to the technical field of pyridineacetamide derivatives, and particularly relates to a pyridineacetamide derivative serving as a CDK inhibitor and a preparation method and application of the pyridine acetamide derivative. The pyridineacetamide derivative shows excellent CDK9/CDK7 enzyme inhibitory activity, and can be used for preparing drugs used for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors such as breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.
Preparation method of ibuprofen impurity A
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Paragraph 0033-0035, (2018/12/02)
The invention discloses a preparation method of an ibuprofen impurity A (shown as a formula I). According to the preparation method, 3-methyl bromophenylacetate is used as a raw material and methyl onhydrogen is removed through alkali; then Suzuki reaction is carried out and the raw material is coupled with isobutaneboronic acid to generate 2-(3-isobutyl phenyl)methyl propionate; finally, the 2-(3-isobutyl phenyl)methyl propionate is hydrolyzed and neutralized to obtain the ibuprofen impurity A. The preparation method disclosed by the invention has the advantages that the raw material is cheap and easy to obtain, synthesis steps are simple, reaction conditions are moderate and the post-treatment is simple; a technology is stable and has good repeatability, so that the production cost isgreatly reduced, and commercial production and batch supply are facilitated.
Stereoselective Ketone Rearrangements with Hypervalent Iodine Reagents
Malmedy, Florence,Wirth, Thomas
supporting information, p. 16072 - 16077 (2016/10/30)
The first stereoselective version of an iodine(III)-mediated rearrangement of arylketones in the presence of orthoesters is described. The reaction products, α-arylated esters, are very useful intermediates in the synthesis of bioactive compounds such as ibuprofen. With chiral lactic acid-based iodine(III) reagents product selectivities of up to 73 % ee have been achieved.
