1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-azetidinecarboxylic acid ammonium salt

Base Information

Chemical Name:1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-azetidinecarboxylic acid ammonium salt
CAS No.:1192829-35-8
Molecular Formula:C₂₄H₂₁ClN₄O₄*H₃N
Molecular Weight:481.939
Hs Code.:

Synonyms:1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-azetidinecarboxylic acid ammonium salt

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Chemical Property of 1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-azetidinecarboxylic acid ammonium salt

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Technology Process of 1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-azetidinecarboxylic acid ammonium salt

There total 8 articles about 1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-azetidinecarboxylic acid ammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192829-65-4
1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

: 36476-78-5
3-azetidinecarboxylic acid

: 1192829-35-8
1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-azetidinecarboxylic acid ammonium salt

Guidance literature:: 3-azetidinecarboxylic acid; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline; In dimethyl sulfoxide; at 120 ℃; Inert atmosphere;

With ammonia; In dimethyl sulfoxide; acetonitrile;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1192829-35-8
1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-azetidinecarboxylic acid ammonium salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; HATU / 2.5 h / 20 - 130 °C / Microwave irradiation

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

3.1: trichlorophosphate / 4.25 h / 20 - 65 °C / Inert atmosphere

4.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 20 °C

4.2: 120 °C / Inert atmosphere

With sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trichlorophosphate; In dichloromethane; dimethyl sulfoxide;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1192829-35-8
1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-azetidinecarboxylic acid ammonium salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: water; sodium hydroxide / methanol / 20 °C

2.2: pH 1 - 2 / Acidification

3.1: triethylamine; HATU / 2.5 h / 20 - 130 °C / Microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

5.1: trichlorophosphate / 4.25 h / 20 - 65 °C / Inert atmosphere

6.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 20 °C

6.2: 120 °C / Inert atmosphere

With water; sodium hydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; sodium hydroxide; trichlorophosphate; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;