4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE

Base Information

• Chemical Name: 4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE
• CAS No.: 26475-62-7
• Molecular Formula: C6H13NO3S
• Molecular Weight: 179.24
• Hs Code.: 2934999090
• Mol file: 26475-62-7.mol

Synonyms:2-(1,1-Dioxothiomorpholino)ethanol;4-(2-Hydroxyethyl)thiomorpholine-1,1-dioxide;4-Thiomorpholineethanol-1-dioxide;1-Dixoide-4-thiomorpholineethanol;

Chemical Property of 4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 74 °C
• Refractive Index: 1.516
• Boiling Point: 403.076 °C at 760 mmHg
• PKA: 14.80±0.10(Predicted)
• Flash Point: 197.574 °C
• PSA: 65.99000
• Density: 1.288 g/cm³
• LogP: -0.27220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: soluble in Methanol

Purity/Quality:

>98.0%(GC)(T) ^*data from raw suppliers

4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE

There total 5 articles about 4-(2-HYDROXYETHYL)THIOMORPHOLINE 1,1-DIOXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.6%

Divinyl sulfone (77-77-0) + ethanolamine (141-43-5) → 4-(2-hydroxyethyl)thiomorpholine 1,1-dioxide (26475-62-7)

Guidance literature:

Divinyl sulfone; ethanolamine; In water; at 20 ℃; for 0.02h; Flow reactor; Large scale;

In water; for 17h; Temperature; Concentration; Solvent; Large scale;

DOI:10.1021/acs.oprd.8b00100

Reference yield: 60.0%

thiomorpholine 1,1-dioxide (39093-93-1) + 2-bromoethanol (540-51-2) → 4-(2-hydroxyethyl)thiomorpholine 1,1-dioxide (26475-62-7)

Guidance literature:

2-bromoethanol; With potassium carbonate; In acetonitrile; at 20 ℃; for 0.5h;

thiomorpholine 1,1-dioxide; In acetonitrile; Reflux;

Reference yield:

1-bromo-2-(2-bromoethanesulfonyl)ethane (7617-67-6) + ethanolamine (141-43-5) → 4-(2-hydroxyethyl)thiomorpholine 1,1-dioxide (26475-62-7)

Guidance literature:

DOI:10.1021/ja01323a021

upstream raw materials:

Divinyl sulfone

ethanolamine

1-bromo-2-(2-bromoethanesulfonyl)ethane

thiomorpholine 1,1-dioxide

Downstream raw materials:

4-(4-chloro-2-fluoroanilino)-7-(2-(1,1-dioxothiomorpholino)ethoxy)-6-methoxyquinazoline

4-(2-(1,1-dioxothiomorpholin-4-yl)ethoxy)benzaldehyde

N,N-bis(2-(1,1-dioxido-4-thiomorpholinyl)ethyl)-2-nitrobenzenesulfonamide

methyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxido-4-thiomorpholinyl)ethyl)amino)-1-isopropenyl-5a,5b,8,8,11a-pentamethyl-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoate

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