methyl 3-((2R,4S,5S)-4-hydroxy-5-(4-methoxyphenyl)-N-hydroxypiperidin-2-yl)propanoate

Base Information

Chemical Name:methyl 3-((2R,4S,5S)-4-hydroxy-5-(4-methoxyphenyl)-N-hydroxypiperidin-2-yl)propanoate
CAS No.:1301743-50-9
Molecular Formula:C₁₆H₂₃NO₅
Molecular Weight:309.362
Hs Code.:

Synonyms:methyl 3-((2R,4S,5S)-4-hydroxy-5-(4-methoxyphenyl)-N-hydroxypiperidin-2-yl)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3-((2R,4S,5S)-4-hydroxy-5-(4-methoxyphenyl)-N-hydroxypiperidin-2-yl)propanoate

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Technology Process of methyl 3-((2R,4S,5S)-4-hydroxy-5-(4-methoxyphenyl)-N-hydroxypiperidin-2-yl)propanoate

There total 3 articles about methyl 3-((2R,4S,5S)-4-hydroxy-5-(4-methoxyphenyl)-N-hydroxypiperidin-2-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1301743-49-6
(3R,4S)-4-hydroxy-6-(3-methoxy-3-oxopropyl)-3-(4-methoxyphenyl)-2,3,4,5-tetrahydropyridine-1-oxide

: 1301743-50-9
methyl 3-((2R,4S,5S)-4-hydroxy-5-(4-methoxyphenyl)-N-hydroxypiperidin-2-yl)propanoate

Guidance literature:: With tetramethylammonium triacetoxyborohydride; In acetic acid; acetonitrile; at 0 ℃; for 1h; stereoselective reaction;
DOI:10.1002/ejoc.201100125

Reference yield:

: 1301743-54-3
methyl 3-(2-((2S, 3R)-2-hydroxy-3-(4-methoxyphenyl)-4-nitrobutyl)-1,3-dioxolan-2-yl)propanoate

: 1301743-50-9
methyl 3-((2R,4S,5S)-4-hydroxy-5-(4-methoxyphenyl)-N-hydroxypiperidin-2-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol; water / 0 - 20 °C

2: ammonium chloride; zinc / tetrahydrofuran; water / 3 h / 20 °C / Inert atmosphere

3: tetramethylammonium triacetoxyborohydride / acetic acid; acetonitrile / 1 h / 0 °C

With hydrogenchloride; ammonium chloride; tetramethylammonium triacetoxyborohydride; zinc; In tetrahydrofuran; methanol; water; acetic acid; acetonitrile;
DOI:10.1002/ejoc.201100125

Reference yield:

: 1301743-48-5
(6S,7R)-methyl 6-hydroxy-7-(4-methoxyphenyl)-8-nitro-4-oxooctanoate

: 1301743-50-9
methyl 3-((2R,4S,5S)-4-hydroxy-5-(4-methoxyphenyl)-N-hydroxypiperidin-2-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; zinc / tetrahydrofuran; water / 3 h / 20 °C / Inert atmosphere

2: tetramethylammonium triacetoxyborohydride / acetic acid; acetonitrile / 1 h / 0 °C

With ammonium chloride; tetramethylammonium triacetoxyborohydride; zinc; In tetrahydrofuran; water; acetic acid; acetonitrile;
DOI:10.1002/ejoc.201100125