1-(4-(methoxycarbonyl)phenyl)-3,3-dimethyl-3,4-dihydroisoquinoline 2-oxide

Base Information

Chemical Name:1-(4-(methoxycarbonyl)phenyl)-3,3-dimethyl-3,4-dihydroisoquinoline 2-oxide
CAS No.:1400303-74-3
Molecular Formula:C₁₉H₁₉NO₃
Molecular Weight:309.365
Hs Code.:

Synonyms:1-(4-(methoxycarbonyl)phenyl)-3,3-dimethyl-3,4-dihydroisoquinoline 2-oxide

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Chemical Property of 1-(4-(methoxycarbonyl)phenyl)-3,3-dimethyl-3,4-dihydroisoquinoline 2-oxide

Chemical Property:

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Technology Process of 1-(4-(methoxycarbonyl)phenyl)-3,3-dimethyl-3,4-dihydroisoquinoline 2-oxide

There total 4 articles about 1-(4-(methoxycarbonyl)phenyl)-3,3-dimethyl-3,4-dihydroisoquinoline 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 619-42-1
4-methoxycarbonylphenyl bromide

: 148671-62-9
3,3-dimethyl-3,4-dihydroisoquinoline N-oxide

: 1400303-74-3
1-(4-(methoxycarbonyl)phenyl)-3,3-dimethyl-3,4-dihydroisoquinoline 2-oxide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; triphenylphosphine; trimethylpyruvic acid; at 150 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo301114k

Reference yield:

: 110871-36-8
4-methyl-N-(2-methyl-1-phenylpropan-2-yl)benzenesulfonamide

: 1400303-74-3
1-(4-(methoxycarbonyl)phenyl)-3,3-dimethyl-3,4-dihydroisoquinoline 2-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: boron trifluoride diethyl etherate / Inert atmosphere

2: ammonia; lithium; toluene-4-sulfonamide / -50 - -33 °C / Inert atmosphere

3: sodium tungstate; dihydrogen peroxide / methanol; water / Inert atmosphere

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; triphenylphosphine; trimethylpyruvic acid / 2 h / 150 °C / Inert atmosphere

With sodium tungstate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; boron trifluoride diethyl etherate; ammonia; dihydrogen peroxide; lithium; potassium carbonate; toluene-4-sulfonamide; triphenylphosphine; trimethylpyruvic acid; In methanol; water;
DOI:10.1021/jo301114k

Reference yield:

: 28459-83-8
3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline

: 1400303-74-3
1-(4-(methoxycarbonyl)phenyl)-3,3-dimethyl-3,4-dihydroisoquinoline 2-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tungstate; dihydrogen peroxide / methanol; water / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; triphenylphosphine; trimethylpyruvic acid / 2 h / 150 °C / Inert atmosphere

With sodium tungstate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dihydrogen peroxide; potassium carbonate; triphenylphosphine; trimethylpyruvic acid; In methanol; water;
DOI:10.1021/jo301114k