110871-36-8

Upstream product

• 1197-21-3 phentermine hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 122-09-8 Phentermin 
• 5048-64-6 2,2-dimethyl-1-(toluene-4-sulfonyl)aziridine 

Downstream Products

• 148671-62-9 3,3-dimethyl-3,4-dihydroisoquinoline N-oxide 
• 1400303-72-1 3,3-dimethyl-1-(p-tolyl)-3,4-dihydroisoquinoline 2-oxide 
• 1400303-73-2 3,3-dimethyl-1-(3,4,5-trimethoxyphenyl)-3,4-dihydroisoquinoline 2-oxide 
• 1400303-74-3 1-(4-(methoxycarbonyl)phenyl)-3,3-dimethyl-3,4-dihydroisoquinoline 2-oxide 
• 28459-83-8 3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline 
• 28460-55-1 3,3-dimethyl-3,4-dihydroisoquinoline 
• 200631-40-9 3,3-dimethyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Fast Pd- and Pd/Cu-catalyzed direct C - H arylation of cyclic nitrones. Application to the synthesis of enantiopure quaternary α-amino esters

Cocatalysis by pivalic acid or copper bromide allows a very fast, clean, and high-yielding palladium-catalyzed coupling of a large array of aryl, thienyl, and pyridyl halides with cyclic nitrones, including DMPO. The study of the reaction conditions, scope, and mechanism is presented. Applied to the chiral nitrone MiPNO, this transformation provides a straightforward access to enantiopure a-methyl α-arylglycine esters.

PICTET-SPENGLER REACTION FOR THE SYNTHESIS OF TETRAHYDROISOQUINOLINES AND RELATED HETEROCYCLIC COMPOUNDS

A commercial scale process for the production of tetrahydroisoquinolines and related heterocyclics by reaction, in mildly acidic conditions, of aryl N-sulfonylethylamines in the presence of suitable Lewis acid, and a compound capable of in situ generation

Reactions with aziridines - 39. Ring opening of activated 2,2-dimethylaziridines by grignard reagents. A mechanistic study

Reaction of activated 2,2-dimethylaziridines 1 with Grignard reagents RMgHal in boiling THF can yield the products 2 of normal aziridine ring opening, the rearranged opening products 3, and the methallylamides 4 (isomers of 1 ). The product distribution depends on R, Hal, and experimental conditions, and very strongly on the nature of the activating group A. It is shown that 1 is opened (reversibly for A = sulfonyl) forming 10 through a Lewis acid assisted attack of Halθ on the tert carbon of 1 (abnormal opening by Halθ ). Evidence is presented to show that 4 as well as 3 come from this intermediate.