Multi-step reaction with 9 steps
1.1: toluene-4-sulfonic acid / 23 h / Heating / reflux
2.1: sodium hydride / tetrahydrofuran / 20 °C
3.1: ammonium acetate / methanol / 2 h / Heating / reflux
4.1: sodium t-butanolate / N,N-dimethyl-formamide / 0.08 h / 160 °C / Microwave
5.1: O-phenyl phosphorodichloridate / 0.5 h / 180 °C
6.1: sodium hydroxide; water / methanol / 4 h / Heating / reflux
6.2: pH 1
7.1: N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C
8.1: methanesulfonic acid / 1,4-dioxane / 0.5 h / 180 °C / Microwave
9.1: hydrogenchloride / diethyl ether; ethyl acetate
With
N-ethylmorpholine;; hydrogenchloride; sodium hydroxide; methanesulfonic acid; ammonium acetate; water; sodium hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; O-phenyl phosphorodichloridate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium t-butanolate;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;