(1R,2R)-3-Benzenesulfonyl-2-methyl-5-phenylsulfanyl-cyclohept-3-enol

Base Information

• Chemical Name: (1R,2R)-3-Benzenesulfonyl-2-methyl-5-phenylsulfanyl-cyclohept-3-enol
• CAS No.: 1019753-19-5
• Molecular Formula: C₂₀H₂₂O₃S₂
• Molecular Weight: 374.525
• Mol file: 1019753-19-5.mol

Synonyms:(1R,2R)-3-Benzenesulfonyl-2-methyl-5-phenylsulfanyl-cyclohept-3-enol

Chemical Property of (1R,2R)-3-Benzenesulfonyl-2-methyl-5-phenylsulfanyl-cyclohept-3-enol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-3-Benzenesulfonyl-2-methyl-5-phenylsulfanyl-cyclohept-3-enol

There total 2 articles about (1R,2R)-3-Benzenesulfonyl-2-methyl-5-phenylsulfanyl-cyclohept-3-enol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methylmagnesium bromide (75-16-1) + diphenyldisulfane (882-33-7) + (R)-3-Benzenesulfonyl-cyclohepta-2,4-dienol (606128-30-7) → (1R,2R)-3-Benzenesulfonyl-2-methyl-5-phenylsulfanyl-cyclohept-4-enol + (1R,2R)-3-Benzenesulfonyl-2-methyl-5-phenylsulfanyl-cyclohept-3-enol (1019753-19-5)

Guidance literature:

methylmagnesium bromide; (R)-3-Benzenesulfonyl-cyclohepta-2,4-dienol; In tetrahydrofuran; toluene; at -70 - 25 ℃;

diphenyldisulfane; In tetrahydrofuran; toluene; at 25 ℃; for 1h; Further stages.;

DOI:10.1021/jo702353e

Reference yield: 94.0%

methylmagnesium bromide (75-16-1) + diphenyldisulfane (882-33-7) + (R)-3-Benzenesulfonyl-cyclohepta-2,4-dienol (606128-30-7) → (1R,2R)-3-Benzenesulfonyl-2-methyl-5-phenylsulfanyl-cyclohept-3-enol (1019753-19-5)

Guidance literature:

(R)-3-Benzenesulfonyl-cyclohepta-2,4-dienol; In tetrahydrofuran; acetone; at -78 ℃; for 0.5h; Inert atmosphere;

methylmagnesium bromide; In tetrahydrofuran; toluene; at -78 ℃; for 1h; Inert atmosphere;

diphenyldisulfane; Further stages;

DOI:10.1021/ol2024746

Reference yield:

(1R,2R)-3-Benzenesulfonyl-2-methyl-5-phenylsulfanyl-cyclohept-3-enol (1019753-19-5) → (1R, 2R, 3R)-3-Benzenesulfonyl-2-methyl-5-phenylsulfanylcyclohept-4-enol + C20H22O3S2 (1019754-21-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 25 ℃; for 0.25h; optical yield given as %de; diastereoselective reaction;

DOI:10.1021/ol2024746

upstream raw materials:

methylmagnesium bromide

diphenyldisulfane

(R)-3-Benzenesulfonyl-cyclohepta-2,4-dienol

Downstream raw materials:

C₂₀H₂₂O₃S₂

C₂₀H₂₂O₃S₂