(S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide

Base Information

Chemical Name:(S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide
CAS No.:1443008-10-3
Molecular Formula:C₂₅H₂₈N₂O₂
Molecular Weight:388.51
Hs Code.:

Synonyms:(S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide

There total 27 articles about (S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₆N₂O₂

: 1443008-10-3
(S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 23 ℃; for 3h; Concentration; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol401337p

Reference yield:

: C₃₀H₃₆N₂O₂

: 1443008-10-3
(S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide

: 1443008-35-2
(R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 23 ℃; for 3h; Concentration; Overall yield = 90 mg; Inert atmosphere;
DOI:10.1021/ol401337p

Reference yield:

: 1443008-03-4
tert-butyl ((R)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

: 1443008-10-3
(S)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide

: 1443008-35-2
(R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethyl-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2.12 h / 0 - 23 °C / Inert atmosphere

2.1: dichloromethane; benzene / 0.83 h / 23 °C / Molecular sieve; Inert atmosphere

3.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 - 0 °C / Inert atmosphere

3.2: 3 h / -50 °C / Inert atmosphere

4.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 23 °C / Inert atmosphere

5.1: water / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 12 h / 0 - 23 °C / Inert atmosphere

7.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.62 h / 0 - 23 °C / Inert atmosphere

8.1: benzene / 0.5 h / 23 °C / 200 Torr / Inert atmosphere

9.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 - 0 °C / Inert atmosphere

9.2: 3.5 h / -50 °C / Inert atmosphere

10.1: hydrogenchloride / tetrahydrofuran; water / 3 h / 23 °C / Inert atmosphere

With hydrogenchloride; water; triethylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; benzene;
DOI:10.1021/ol401337p