(R)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

Base Information

Chemical Name:(R)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide
CAS No.:1443007-93-9
Molecular Formula:C₂₃H₃₀N₂O₂
Molecular Weight:366.503
Hs Code.:

Synonyms:(R)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

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Chemical Property of (R)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

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Technology Process of (R)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

There total 20 articles about (R)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1443008-08-9
(E)-N-(2,2-dimethylpropylidene)propan-1-amine

: 1443008-05-6
(R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

: 1443007-93-9
(R)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

Guidance literature:: In benzene; at 23 ℃; for 0.5h; under 200 Torr; Inert atmosphere;
DOI:10.1021/ol401337p

Reference yield: 99.0%

: 1443008-05-6
(R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

: 630-19-3
pivalaldehyde

: 1443007-93-9
(R)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

Guidance literature:: In dichloromethane; benzene; at 23 ℃; for 0.833333h; Molecular sieve; Inert atmosphere;
DOI:10.1021/ol401337p

Reference yield:

: 1443008-04-5
tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

: 1443007-93-9
(R)-2-((E)-(2,2-dimethylpropylidene)amino)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 1.62 h / 0 - 23 °C / Inert atmosphere

2.1: benzene / 0.5 h / 23 °C / 200 Torr / Inert atmosphere

3.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 - 0 °C / Inert atmosphere

3.2: 3.5 h / -50 °C / Inert atmosphere

4.1: hydrogenchloride / tetrahydrofuran; water / 3 h / 23 °C / Inert atmosphere

5.1: water / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 12 h / 0 - 23 °C / Inert atmosphere

7.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2.12 h / 0 - 23 °C / Inert atmosphere

8.1: dichloromethane; benzene / 0.83 h / 23 °C / Molecular sieve; Inert atmosphere

With hydrogenchloride; water; triethylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; benzene;
DOI:10.1021/ol401337p