tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate
CAS No.:1443008-04-5
Molecular Formula:C₂₃H₃₀N₂O₄
Molecular Weight:398.502
Hs Code.:

Synonyms:tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

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Chemical Property of tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

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Technology Process of tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

There total 14 articles about tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443008-03-4
tert-butyl ((R)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

: 1443008-04-5
tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2.12 h / 0 - 23 °C / Inert atmosphere

2.1: dichloromethane; benzene / 0.83 h / 23 °C / Molecular sieve; Inert atmosphere

3.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 - 0 °C / Inert atmosphere

3.2: 3 h / -50 °C / Inert atmosphere

4.1: hydrogenchloride / tetrahydrofuran; water / 12 h / 23 °C / Inert atmosphere

5.1: water / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 12 h / 0 - 23 °C / Inert atmosphere

With hydrogenchloride; water; triethylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; benzene;
DOI:10.1021/ol401337p

Reference yield:

: 550-58-3,20616-51-7,20616-52-8,46797-67-5,53176-60-6,54852-85-6,75196-48-4,90365-73-4
(1R,2S)-1,2-diphenyl-2-(N-methyl)aminoethanol

: 631914-55-1
Boc-L-Ala-Cl

: 1443008-04-5
tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 23 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol401337p

Reference yield:

: 1443008-05-6
(R)-2-amino-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N-methylpropanamide

: 1443008-04-5
tert-butyl ((S)-1-(((1S,2S)-2-hydroxy-1,2-diphenylethyl)(methyl)amino)-1-oxopropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane; benzene / 0.83 h / 23 °C / Molecular sieve; Inert atmosphere

2.1: lithium chloride; lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -78 - 0 °C / Inert atmosphere

2.2: 3 h / -50 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride / water; ethyl acetate / 1.5 h / 23 °C / pH 6 / Inert atmosphere

4.1: water / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 12 h / 0 - 23 °C / Inert atmosphere

With hydroxylamine hydrochloride; water; triethylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; benzene;
DOI:10.1021/ol401337p