cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Base Information

Chemical Name:cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine
CAS No.:1357001-74-1
Molecular Formula:C₃₃H₃₃F₂N₃O
Molecular Weight:525.641
Hs Code.:

Synonyms:cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

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Chemical Property of cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

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Technology Process of cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

There total 4 articles about cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1357001-61-6
cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 1357001-74-1
cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine; Cinnamoyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 120 ℃; for 0.166667h; Microwave irradiation;

With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 2h;

Reference yield:

: 1002916-54-2
[8-(3-Fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethyl-amine hydrochloride

: 1357001-74-1
cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / 96 h / 20 °C

1.2: cooling with ice

2.1: trifluoroacetic acid / ethanol / 12 h / Reflux

2.2: 12 h / 20 °C

2.3: 0 °C / Basic conditions

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 120 °C / Microwave irradiation

3.2: 2 h / 20 °C

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane;

Reference yield:

: 863514-54-9
4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one

: 1357001-74-1
cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / ethanol / 12 h / Reflux

1.2: 12 h / 20 °C

1.3: 0 °C / Basic conditions

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 120 °C / Microwave irradiation

2.2: 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane;