cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Base Information

Chemical Name:cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine
CAS No.:1357001-61-6
Molecular Formula:C₂₄H₂₇F₂N₃
Molecular Weight:395.495
Hs Code.:

Synonyms:cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

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Chemical Property of cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

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Technology Process of cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

There total 2 articles about cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 863514-54-9
4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one

: 576-16-9
5-fluorotryptamine

: 1357001-61-6
cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: 4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one; 5-fluorotryptamine; With trifluoroacetic acid; In ethanol; for 12h; Reflux;

With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 12h;

With sodium hydroxide; In 1,2-dichloro-ethane; at 0 ℃; Basic conditions;

Reference yield:

: 1002916-54-2
[8-(3-Fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethyl-amine hydrochloride

: 1357001-61-6
cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / 96 h / 20 °C

1.2: cooling with ice

2.1: trifluoroacetic acid / ethanol / 12 h / Reflux

2.2: 12 h / 20 °C

2.3: 0 °C / Basic conditions

With hydrogenchloride; water; trifluoroacetic acid; In ethanol;

Reference yield: 45.0%

: 1357001-61-6
cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

: 103-80-0
phenylacetyl chloride

: 1357001-75-2
cis-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(benzyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine; phenylacetyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 120 ℃; for 0.166667h; Microwave irradiation;

With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 2h;