(+)-(3S)-3-[(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptan-1-yl]-4,5,6,7-tetrahydroisobenzofuran-1(3H)-one

Base Information

Chemical Name:(+)-(3S)-3-[(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptan-1-yl]-4,5,6,7-tetrahydroisobenzofuran-1(3H)-one
CAS No.:301823-93-8
Molecular Formula:C₃₄H₄₂O₄Si
Molecular Weight:542.791
Hs Code.:

Synonyms:(+)-(3S)-3-[(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptan-1-yl]-4,5,6,7-tetrahydroisobenzofuran-1(3H)-one

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Chemical Property of (+)-(3S)-3-[(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptan-1-yl]-4,5,6,7-tetrahydroisobenzofuran-1(3H)-one

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Technology Process of (+)-(3S)-3-[(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptan-1-yl]-4,5,6,7-tetrahydroisobenzofuran-1(3H)-one

There total 16 articles about (+)-(3S)-3-[(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptan-1-yl]-4,5,6,7-tetrahydroisobenzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 122135-83-5
ethyl 2-trifluoromethanesulfonyloxycyclohex-1-enecarboxylate

: 301823-94-9
(+)-(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptancarboxaldehyde

: 301823-93-8
(+)-(3S)-3-[(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptan-1-yl]-4,5,6,7-tetrahydroisobenzofuran-1(3H)-one

: (R)-3-[(1R,2S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxy)-3,3-dimethyl-2-vinyl-7-oxa-bicyclo[2.2.1]hept-1-yl]-4,5,6,7-tetrahydro-3H-isobenzofuran-1-one

Guidance literature:: With chromium dichloride; nickel dichloride; In N,N-dimethyl-formamide; at 50 ℃; for 18h;
DOI:10.1039/b202020n

Reference yield:

: 122135-83-5
ethyl 2-trifluoromethanesulfonyloxycyclohex-1-enecarboxylate

: 301823-94-9
(+)-(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptancarboxaldehyde

: 301823-93-8
(+)-(3S)-3-[(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptan-1-yl]-4,5,6,7-tetrahydroisobenzofuran-1(3H)-one

Guidance literature:: With chromium dichloride; nickel dichloride; In N,N-dimethyl-formamide; at 50 ℃;
DOI:10.1039/b003757p

Reference yield:

: 471269-89-3
(+)-(1R,2S,4R,5S)-[5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptan-1-yl]methanol

: 301823-93-8
(+)-(3S)-3-[(1R,2S,4R,5S)-5-(tert-butyldiphenylsilyloxy)-3,3-dimethyl-2-vinyl-7-oxabicyclo[2.2.1]heptan-1-yl]-4,5,6,7-tetrahydroisobenzofuran-1(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / SO₃*pyridine; DMSO / CH₂Cl₂ / 3 h / 20 °C

2: 64 percent / CrCl₂ / NiCl₂ / dimethylformamide / 18 h / 50 °C

With chromium dichloride; pyridine-SO₃ complex; dimethyl sulfoxide; nickel dichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b202020n