11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-thione

• Chemical Name: 11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-thione
• Molecular Formula: C₂₄H₂₀N₂O₂S
• Molecular Weight: 400.501
• Mol file: 115757-50-1.mol

Synonyms:11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-thione

Chemical Property of 11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzo

Chemical Property:

Purity/Quality:

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Technology Process of 11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzo

There total 5 articles about 11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-one (104669-20-7) → 11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-thione (115757-50-1)

Guidance literature:

With tetraphosphorus decasulfide; In pyridine; for 3h; Heating;

DOI:10.1021/jo00253a014

Reference yield:

3-pyridinecarbonyl chloride (10400-19-8) → 11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-thione (115757-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / triethylamine / benzene / Ambient temperature

2: 27 percent / benzene / 4.5 h / 15 - 20 °C / Irradiation

3: 64 percent / phosphorus pentasulfide / pyridine / 12 h / Heating

With diphosphorus pentasulfide; triethylamine; In pyridine; benzene;

DOI:10.1016/S0040-4020(01)85978-0

Reference yield:

7-(benzyloxy)-6-methoxy-1-methyl-3,4-dihydroisoquinoline (78867-50-2) → 11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-thione (115757-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / triethylamine / benzene / Ambient temperature

2: 27 percent / benzene / 4.5 h / 15 - 20 °C / Irradiation

3: 64 percent / phosphorus pentasulfide / pyridine / 12 h / Heating

With diphosphorus pentasulfide; triethylamine; In pyridine; benzene;

DOI:10.1016/S0040-4020(01)85978-0

upstream raw materials:

11-benzyloxy-10-methoxy-7,8-dihydro-5H-benzopyrido<3,4-g>quinolizin-5-one

3-pyridinecarbonyl chloride

7-(benzyloxy)-6-methoxy-1-methyl-3,4-dihydroisoquinoline

sodium nicotinate

Downstream raw materials:

(6aR,12aS)-2-Benzyloxy-3-methoxy-5,7,12,12a-tetrahydro-6H-6a,9-diaza-benzo[a]anthracene