(E)-1-(tert-Butyl-dimethyl-silanyl)-2-phenyl-ethenesulfonic acid cyclohexyl-methyl-amide

Base Information

• Chemical Name: (E)-1-(tert-Butyl-dimethyl-silanyl)-2-phenyl-ethenesulfonic acid cyclohexyl-methyl-amide
• CAS No.: 210300-80-4
• Molecular Formula: C₂₁H₃₅NO₂SSi
• Molecular Weight: 393.666
• Mol file: 210300-80-4.mol

Synonyms:(E)-1-(tert-Butyl-dimethyl-silanyl)-2-phenyl-ethenesulfonic acid cyclohexyl-methyl-amide

Chemical Property of (E)-1-(tert-Butyl-dimethyl-silanyl)-2-phenyl-ethenesulfonic acid cyclohexyl-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(tert-Butyl-dimethyl-silanyl)-2-phenyl-ethenesulfonic acid cyclohexyl-methyl-amide

There total 2 articles about (E)-1-(tert-Butyl-dimethyl-silanyl)-2-phenyl-ethenesulfonic acid cyclohexyl-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phenyl(methylidene)cyclohexanamine (2211-66-7) → (E)-1-(tert-Butyl-dimethyl-silanyl)-2-phenyl-ethenesulfonic acid cyclohexyl-methyl-amide (210300-80-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / tetrahydrofuran / 312 h / Ambient temperature

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, RT, 12 h

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1248/cpb.46.757

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) + 2-Cyclohexyl-3-phenyl-1,2-thiazetidin-1,1-dioxid (97273-03-5) → (E)-N-cyclohexyl-2-phenylethenesulfonamide (13719-46-5) + (E)-1-(tert-Butyl-dimethyl-silanyl)-2-phenyl-ethenesulfonic acid cyclohexylamide + (E)-1-(tert-Butyl-dimethyl-silanyl)-2-phenyl-ethenesulfonic acid cyclohexyl-methyl-amide (210300-80-4)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, RT, 12 h;

DOI:10.1248/cpb.46.757

Reference yield: 79.0%

(E)-1-(tert-Butyl-dimethyl-silanyl)-2-phenyl-ethenesulfonic acid cyclohexyl-methyl-amide (210300-80-4) → (E)-2-Phenyl-ethenesulfonic acid cyclohexyl-methyl-amide

Guidance literature:

With tetrabutyl ammonium fluoride; benzaldehyde; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1248/cpb.46.757

upstream raw materials:

tert-butyldimethylsilyl chloride

2-Cyclohexyl-3-phenyl-1,2-thiazetidin-1,1-dioxid

N-phenyl(methylidene)cyclohexanamine