{4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile

Base Information

Chemical Name:{4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile
CAS No.:1251936-40-9
Molecular Formula:C₃₈H₃₂N₂O₃
Molecular Weight:564.684
Hs Code.:

Synonyms:{4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile

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Chemical Property of {4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile

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Technology Process of {4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile

There total 5 articles about {4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35081-45-9
1-<4-(benzyloxy)phenyl>-2-bromo-1-propanone

: C₂₂H₂₀N₂O₂

: 1251936-40-9
{4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 120 ℃; for 6h;

Reference yield:

: 123226-38-0
4-hydroxymethyl-phenoxy acetonitrile

: 1251936-40-9
{4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 0 - 5 °C

2.1: sodium amide / N,N-dimethyl-formamide / 0.25 h / 10 - 15 °C

2.2: 10 - 15 °C

With thionyl chloride; sodium amide; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 623-05-2
(4-hydroxyphenyl)methanol

: 1251936-40-9
{4-[5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-indol-1-ylmethyl]-phenoxy}-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 0.25 h

1.2: 7 h / 55 - 56 °C

2.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 0 - 5 °C

3.1: sodium amide / N,N-dimethyl-formamide / 0.25 h / 10 - 15 °C

3.2: 10 - 15 °C

With thionyl chloride; potassium carbonate; sodium amide; In N,N-dimethyl-formamide; acetone; toluene;