(R)-4-{(5R,7R,8R,9S,10S,13R,14S,17R)-7-Hydroxy-2-[1-hydroxy-meth-(E)-ylidene]-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

Base Information

Chemical Name:(R)-4-{(5R,7R,8R,9S,10S,13R,14S,17R)-7-Hydroxy-2-[1-hydroxy-meth-(E)-ylidene]-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester
CAS No.:832729-22-3
Molecular Formula:C₂₆H₄₀O₅
Molecular Weight:432.601
Hs Code.:

(R)-4-{(5R,7R,8R,9S,10S,13R,14S,17R)-7-Hydroxy-2-[1-hydroxy-meth-(E)-ylidene]-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

Synonyms:(R)-4-{(5R,7R,8R,9S,10S,13R,14S,17R)-7-Hydroxy-2-[1-hydroxy-meth-(E)-ylidene]-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

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Chemical Property of (R)-4-{(5R,7R,8R,9S,10S,13R,14S,17R)-7-Hydroxy-2-[1-hydroxy-meth-(E)-ylidene]-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

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Technology Process of (R)-4-{(5R,7R,8R,9S,10S,13R,14S,17R)-7-Hydroxy-2-[1-hydroxy-meth-(E)-ylidene]-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

There total 1 articles about (R)-4-{(5R,7R,8R,9S,10S,13R,14S,17R)-7-Hydroxy-2-[1-hydroxy-meth-(E)-ylidene]-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14773-00-3
methyl (5β,7α)-12-hydroxy-3-oxo-cholan-24-oate

: 109-94-4
formic acid ethyl ester

: 832729-22-3
(R)-4-{(5R,7R,8R,9S,10S,13R,14S,17R)-7-Hydroxy-2-[1-hydroxy-meth-(E)-ylidene]-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

Guidance literature:: With ethanol; sodium hydride; In toluene; at 20 ℃;
DOI:10.1016/j.bmcl.2004.10.027

Reference yield:

: 832729-22-3
(R)-4-{(5R,7R,8R,9S,10S,13R,14S,17R)-7-Hydroxy-2-[1-hydroxy-meth-(E)-ylidene]-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

: {(R)-4-[(1R,3aS,3bR,4R,5aS,10aS,10bS,12aR)-4-Hydroxy-8-(3-hydroxy-benzyl)-10a,12a-dimethyl-1,2,3,3a,3b,4,5,5a,6,8,10,10a,10b,11,12,12a-hexadecahydro-7,8-diaza-dicyclopenta[a,h]phenanthren-1-yl]-pentanoylamino}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / Heating

2: aq. NaOH / tetrahydrofuran / 20 °C

3: EDAC; DIEA / CH₂Cl₂ / 20 °C

4: HCl / dioxane / 20 °C

With hydrogenchloride; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.10.027

Reference yield:

: 832729-22-3
(R)-4-{(5R,7R,8R,9S,10S,13R,14S,17R)-7-Hydroxy-2-[1-hydroxy-meth-(E)-ylidene]-10,13-dimethyl-3-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

: 501120-09-8
{(R)-4-[(1R,3aS,3bR,4R,5aS,10aS,10bS,12aR)-4-Hydroxy-8-(3-hydroxy-benzyl)-10a,12a-dimethyl-1,2,3,3a,3b,4,5,5a,6,8,10,10a,10b,11,12,12a-hexadecahydro-7,8-diaza-dicyclopenta[a,h]phenanthren-1-yl]-pentanoylamino}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / Heating

2: aq. NaOH / tetrahydrofuran / 20 °C

3: EDAC; DIEA / CH₂Cl₂ / 20 °C

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.10.027