(R)-3-[(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoyl]-4-phenyloxazolidin-2-one

Base Information

Chemical Name:(R)-3-[(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoyl]-4-phenyloxazolidin-2-one
CAS No.:1260083-80-4
Molecular Formula:C₂₂H₂₅NO₅
Molecular Weight:383.444
Hs Code.:

Synonyms:(R)-3-[(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoyl]-4-phenyloxazolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-[(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoyl]-4-phenyloxazolidin-2-one

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Technology Process of (R)-3-[(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoyl]-4-phenyloxazolidin-2-one

There total 3 articles about (R)-3-[(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoyl]-4-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1329428-58-1
(R,E)-3-[3-(2,5-dimethoxy-4-methylphenyl)acryloyl]-4-phenyloxazolidin-2-one

: 75-16-1
methylmagnesium bromide

: 1260083-80-4
(R)-3-[(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoyl]-4-phenyloxazolidin-2-one

: (R)-3-[(S)-3-(2,5-dimethoxy-4-methylphenyl)butanoyl]-4-phenyloxazolidin-2-one

Guidance literature:: methylmagnesium bromide; With copper(I) bromide dimethylsulfide complex; dimethylsulfide; In tetrahydrofuran; at -4 ℃; for 0.166667h; Inert atmosphere;

(R,E)-3-[3-(2,5-dimethoxy-4-methylphenyl)acryloyl]-4-phenyloxazolidin-2-one; In tetrahydrofuran; at -20 ℃; for 0.5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2011.03.064

Reference yield: 71.0%

: 1304119-53-6
C₂₁H₂₁NO₅

: 75-16-1
methylmagnesium bromide

: 1260083-80-4
(R)-3-[(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoyl]-4-phenyloxazolidin-2-one

Guidance literature:: With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -20 ℃;
DOI:10.1016/j.tetasy.2010.08.018

Reference yield:

: 13321-74-9
1-bromo-2,5-dimethoxy-4-methylbenzene

: 133940-76-8
(4R)-3-acryloyl-4-phenyl-1,3-oxazolidin-2-one

: 1260083-80-4
(R)-3-[(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoyl]-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / water; acetonitrile / 2 h / 80 °C

2: copper(I) bromide dimethylsulfide complex / tetrahydrofuran / 0.5 h / -20 °C

With copper(I) bromide dimethylsulfide complex; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; water; acetonitrile; 1: Heck coupling;
DOI:10.1016/j.tetlet.2011.12.115