(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoic acid

Base Information

• Chemical Name: (R)-3-(2,5-dimethoxy-4-methylphenyl)butanoic acid
• CAS No.: 1313051-72-7
• Molecular Formula: C₁₃H₂₀O₃
• Molecular Weight: 224.3
• Mol file: 1313051-72-7.mol

Synonyms:(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoic acid

Chemical Property of (R)-3-(2,5-dimethoxy-4-methylphenyl)butanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-(2,5-dimethoxy-4-methylphenyl)butanoic acid

There total 13 articles about (R)-3-(2,5-dimethoxy-4-methylphenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(R)-3-[(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoyl]-4-phenyloxazolidin-2-one (1260083-80-4) → (R)-3-(2,5-dimethoxy-4-methylphenyl)butanoic acid (1313051-72-7)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 50 ℃; for 3.5h; Inert atmosphere;

DOI:10.1016/j.tet.2011.03.064

Reference yield:

(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoic acid (528606-20-4) → (R)-3-(2,5-dimethoxy-4-methylphenyl)butanoic acid (1313051-72-7)

Guidance literature:

(R)-3-(2,5-dimethoxy-4-methylphenyl)butanoic acid; With lithium aluminium tetrahydride; In diethyl ether; for 1h; Inert atmosphere; Reflux;

With hydrogenchloride; In diethyl ether; water; at 0 ℃;

DOI:10.1016/j.tetasy.2011.03.012

Reference yield:

1-(2,5-Dimethoxy-4-methyl-phenyl)-ethanone (13720-58-6) → (R)-3-(2,5-dimethoxy-4-methylphenyl)butanoic acid (1313051-72-7)

Guidance literature:

Multi-step reaction with 9 steps

1.1: diethyl ether / 3.5 h / 0 - 20 °C / Inert atmosphere

1.2: Cooling with ice

2.1: toluene-4-sulfonic acid; hydroquinone / benzene / Reflux; Azeotropic water removal

3.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.2: 1 h / 20 - 40 °C

3.3: 20 - 30 °C

4.1: Porcine pancreas lipase type II / tert-butyl methyl ether / 20 °C / Enzymatic reaction

5.1: methanol; sodium hydroxide

6.1: pyridine / 4 h

7.1: dimethyl sulfoxide / 3 h / 80 °C

8.1: sodium hydroxide / 12 h / Reflux

9.1: lithium aluminium tetrahydride / diethyl ether / 1 h / Inert atmosphere; Reflux

9.2: 0 °C

With pyridine; methanol; lithium aluminium tetrahydride; Porcine pancreas lipase type II; dimethylsulfide borane complex; toluene-4-sulfonic acid; hydroquinone; sodium hydroxide; In tetrahydrofuran; diethyl ether; tert-butyl methyl ether; dimethyl sulfoxide; benzene;

DOI:10.1016/j.tetasy.2011.03.012

upstream raw materials:

1,4-dimethoxy-2-methyl-5-(prop-1-en-2-yl)benzene

2-(2,5-dimethoxy-4-methylphenyl)propan-1-ol

2-(2,5-Dimethoxy-4-methyl-phenyl)-propan-2-ol

1-(2,5-Dimethoxy-4-methyl-phenyl)-ethanone

Downstream raw materials:

(R)-1,4-dimethoxy-2-(5-methoxypent-4-en-2-yl)-5-methylbenzene

(R)-4-(2,5-dimethoxy-4-methylphenyl)pentanal

(3S,6R)-6-(2,5-dimethoxy-4-methylphenyl)-2-methylheptane-2,3-diol

2-[(2R,5S)-5,6-dihydroxy-6-methylheptan-2-yl]-5-methylcyclohexa-2,5-diene-1,4-dione