Phenol, 4-bromo-2-ethoxy- (9CI)

Base Information

• Chemical Name: Phenol, 4-bromo-2-ethoxy- (9CI)
• CAS No.: 211495-66-8
• Molecular Formula: C₈H₉BrO₂
• Molecular Weight: 217.062
• Mol file: 211495-66-8.mol

Synonyms:Phenol, 4-bromo-2-ethoxy- (9CI)

Chemical Property of Phenol, 4-bromo-2-ethoxy- (9CI)

Chemical Property:

• Boiling Point: 265.8±20.0 °C(Predicted)
• PKA: 9.53±0.18(Predicted)
• PSA: 0.00000
• Density: 1.501±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

99%, ^*data from raw suppliers

4-Bromo-2-ethoxyphenol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 4-bromo-2-ethoxy- (9CI)

There total 1 articles about Phenol, 4-bromo-2-ethoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Ethoxyphenol (94-71-3) → 4-Bromo-2-ethoxy-phenol (211495-66-8)

Guidance literature:

With bis(trichloromethyl) carbonate; tetrabutylammomium bromide; potassium bromide; In water; ethyl acetate; at 20 ℃; for 19h; regioselective reaction;

DOI:10.1016/j.tet.2019.130539

Reference yield:

4-Bromo-2-ethoxy-phenol (211495-66-8) + benzyl bromide (100-39-0) → C15H15BrO2

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 2h;

DOI:10.3390/ijms22115910

Reference yield:

4-Bromo-2-ethoxy-phenol (211495-66-8) → C14H16N2O4

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C

2: n-butyllithium / tetrahydrofuran / 1 h / -78 - 20 °C

3: tin(IV) chloride / dichloromethane / 0.5 h / -78 - 20 °C

4: nitric acid; acetic acid / acetic anhydride / 1 h / 0 °C

5: aluminum (III) chloride / dichloromethane / 1 h / 0 °C

With aluminum (III) chloride; n-butyllithium; nitric acid; tin(IV) chloride; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; acetic anhydride; N,N-dimethyl-formamide;

DOI:10.3390/ijms22115910

upstream raw materials:

2-Ethoxyphenol

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