(S)-1-benzoyl-2-isopropyl-5-((trimethylsilyl)ethynyl)-2,3-dihydropyrimidin-4(1H)-one

Base Information

Chemical Name:(S)-1-benzoyl-2-isopropyl-5-((trimethylsilyl)ethynyl)-2,3-dihydropyrimidin-4(1H)-one
CAS No.:1273415-57-8
Molecular Formula:C₁₉H₂₄N₂O₂Si
Molecular Weight:340.497
Hs Code.:

Synonyms:(S)-1-benzoyl-2-isopropyl-5-((trimethylsilyl)ethynyl)-2,3-dihydropyrimidin-4(1H)-one

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Chemical Property of (S)-1-benzoyl-2-isopropyl-5-((trimethylsilyl)ethynyl)-2,3-dihydropyrimidin-4(1H)-one

Chemical Property:

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Technology Process of (S)-1-benzoyl-2-isopropyl-5-((trimethylsilyl)ethynyl)-2,3-dihydropyrimidin-4(1H)-one

There total 3 articles about (S)-1-benzoyl-2-isopropyl-5-((trimethylsilyl)ethynyl)-2,3-dihydropyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,6S)-2-isopropylperhydropyrimidin-4-one-6-carboxylic acid

: 1273415-57-8
(S)-1-benzoyl-2-isopropyl-5-((trimethylsilyl)ethynyl)-2,3-dihydropyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water / 0 °C

2.1: [bis(acetoxy)iodo]benzene; iodine / dichloromethane / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

With copper(l) iodide; [bis(acetoxy)iodo]benzene; iodine; sodium hydrogencarbonate; triethylamine; triphenylphosphine; palladium dichloride; In dichloromethane; water; acetonitrile; 3.1: Sonogashira coupling;
DOI:10.1016/j.tetlet.2011.10.011

Reference yield:

: 98-88-4
benzoyl chloride

: 1273415-57-8
(S)-1-benzoyl-2-isopropyl-5-((trimethylsilyl)ethynyl)-2,3-dihydropyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water / 0 °C

2.1: [bis(acetoxy)iodo]benzene; iodine / dichloromethane / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

With copper(l) iodide; [bis(acetoxy)iodo]benzene; iodine; sodium hydrogencarbonate; triethylamine; triphenylphosphine; palladium dichloride; In dichloromethane; water; acetonitrile; 3.1: Sonogashira coupling;
DOI:10.1016/j.tetlet.2011.10.011

Reference yield:

: 211686-52-1
1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one

: 1273415-57-8
(S)-1-benzoyl-2-isopropyl-5-((trimethylsilyl)ethynyl)-2,3-dihydropyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: [bis(acetoxy)iodo]benzene; iodine / dichloromethane / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

With copper(l) iodide; [bis(acetoxy)iodo]benzene; iodine; triethylamine; triphenylphosphine; palladium dichloride; In dichloromethane; acetonitrile; 2.1: Sonogashira coupling;
DOI:10.1016/j.tetlet.2011.10.011