1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one

Base Information

• Chemical Name: 1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one
• CAS No.: 211686-52-1
• Molecular Formula: C₁₅H₁₈N₂O₄
• Molecular Weight: 290.319
• Mol file: 211686-52-1.mol

Synonyms:1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one

Chemical Property of 1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one

There total 3 articles about 1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,6S)-2-isopropylperhydropyrimidin-4-one-6-carboxylic acid + benzoyl chloride (98-88-4) → 1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one (211686-52-1)

Guidance literature:

With sodium hydrogencarbonate;

DOI:10.1016/j.tet.2005.06.094

Reference yield:

L-asparagine (70-47-3,28088-48-4,7006-34-0) + benzoyl chloride (98-88-4) + isobutyraldehyde (78-84-2) → 1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one (211686-52-1)

Guidance literature:

With potassium hydroxide; sodium hydrogencarbonate; Yield given. Multistep reaction; 1) MeOH, rt, 10 min; 2) MeOH, reflux, 10 h; 3) MeOH, rt, overnight;

DOI:10.1021/jo980367a

Reference yield:

C7H13IN2O2 + benzoyl chloride (98-88-4) → 1-benzoyl-2(S)-isopropyl-6(S)-carboxy-perhydropyrimidin-4-one (211686-52-1)

Guidance literature:

With sodium hydrogencarbonate; In water; at 0 ℃;

DOI:10.1002/ejoc.201000852

upstream raw materials:

L-asparagine

benzoyl chloride

isobutyraldehyde

Downstream raw materials:

1-benzoyl-5-iodo-(2S)-isopropyl-2,3-dihydro-4(H)-pyrimidin-4-one

(S)-1-benzoyl-5-(1-cyclohexyl-1H-1,2,3-triazol-4-yl)-2-isopropyl-2,3-dihydropyrimidin-4(1H)-one

(S)-1-benzoyl-5-(1-hexyl-1H-1,2,3-triazol-4-yl)-2-isopropyl-2,3-dihydropyrimidin-4(1H)-one

(S)-1-benzoyl-2-isopropyl-5-(1-octyl-1H-1,2,3-triazol-4-yl)-2,3-dihydropyrimidin-4(1H)-one