Methanesulfonic acid (1R,3R,4R,7R)-3-(6-benzoylamino-purin-9-yl)-7-benzyloxy-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester

Base Information

Chemical Name:Methanesulfonic acid (1R,3R,4R,7R)-3-(6-benzoylamino-purin-9-yl)-7-benzyloxy-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester
CAS No.:673456-38-7
Molecular Formula:C₂₆H₂₅N₅O₇S
Molecular Weight:551.58
Hs Code.:

Synonyms:Methanesulfonic acid (1R,3R,4R,7R)-3-(6-benzoylamino-purin-9-yl)-7-benzyloxy-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester

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Chemical Property of Methanesulfonic acid (1R,3R,4R,7R)-3-(6-benzoylamino-purin-9-yl)-7-benzyloxy-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester

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Technology Process of Methanesulfonic acid (1R,3R,4R,7R)-3-(6-benzoylamino-purin-9-yl)-7-benzyloxy-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester

There total 6 articles about Methanesulfonic acid (1R,3R,4R,7R)-3-(6-benzoylamino-purin-9-yl)-7-benzyloxy-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 341536-45-6
9-[2-O-acetyl-5-O-benzoyl-4-C-[(benzoyloxy)methyl]-3-O-benzyl-α-L-threo-pentofuranosyl]-6-N-benzoyladenine

: 673456-38-7
Methanesulfonic acid (1R,3R,4R,7R)-3-(6-benzoylamino-purin-9-yl)-7-benzyloxy-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 85 percent / NH₃ / methanol

2.1: 72 percent / imidazole / dimethylformamide

3.1: 94 percent / NH₃ / methanol

4.1: trimethylsilyl chloride; pyridine

4.2: pyridine

4.3: NH₃ / methanol; H₂O

5.1: pyridine

6.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

7.1: 83 percent / sodium hydride / dimethylformamide

With pyridine; 1H-imidazole; chloro-trimethyl-silane; tetrabutyl ammonium fluoride; ammonia; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1081/NCN-120022826

Reference yield:

: 673456-34-3
C₃₉H₃₃N₅O₈

: 673456-38-7
Methanesulfonic acid (1R,3R,4R,7R)-3-(6-benzoylamino-purin-9-yl)-7-benzyloxy-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 72 percent / imidazole / dimethylformamide

2.1: 94 percent / NH₃ / methanol

3.1: trimethylsilyl chloride; pyridine

3.2: pyridine

3.3: NH₃ / methanol; H₂O

4.1: pyridine

5.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

6.1: 83 percent / sodium hydride / dimethylformamide

With pyridine; 1H-imidazole; chloro-trimethyl-silane; tetrabutyl ammonium fluoride; ammonia; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1081/NCN-120022826

Reference yield:

: 673456-36-5
[(3R,4R,5R)-5-(6-Amino-purin-9-yl)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-tetrahydro-furan-2-yl]-methanol

: 673456-38-7
Methanesulfonic acid (1R,3R,4R,7R)-3-(6-benzoylamino-purin-9-yl)-7-benzyloxy-2,5-dioxa-bicyclo[2.2.1]hept-1-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylsilyl chloride; pyridine

1.2: pyridine

1.3: NH₃ / methanol; H₂O

2.1: pyridine

3.1: 87 percent / tetrabutylammonium fluoride / tetrahydrofuran

4.1: 83 percent / sodium hydride / dimethylformamide

With pyridine; chloro-trimethyl-silane; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1081/NCN-120022826