(S)-3((benzyloxycarbonyl)amino)-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepin-2-one

Base Information

Chemical Name:(S)-3((benzyloxycarbonyl)amino)-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepin-2-one
CAS No.:140677-47-0
Molecular Formula:C₁₆H₁₇N₃O₃
Molecular Weight:299.329
Hs Code.:

Synonyms:(S)-3((benzyloxycarbonyl)amino)-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepin-2-one

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Chemical Property of (S)-3((benzyloxycarbonyl)amino)-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepin-2-one

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Technology Process of (S)-3((benzyloxycarbonyl)amino)-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepin-2-one

There total 6 articles about (S)-3((benzyloxycarbonyl)amino)-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 140677-46-9
(S)-2-((benzyloxycarbonyl)amino)-4-(1-amino-2-pyrrolyl)butanoic acid

: 140677-47-0
(S)-3((benzyloxycarbonyl)amino)-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepin-2-one

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/jo00039a007

Reference yield:

: 58456-26-1
(S)-4-<2'-(Chloroformyl)ethyl>-5-oxooxazolidin-3-carbonsaeure-benzylester

: 140677-47-0
(S)-3((benzyloxycarbonyl)amino)-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1) Mg / 1) THF, r.t., 30 min, 2) THF, -65 deg C, 1 h

2: 83 percent / 1 N NaOH / methanol / Ambient temperature

3: 23 percent / 20percent HCl / tetrahydrofuran / 0.25 h / 50 °C

4: 75 percent / N₂H₄*H₂O / methanol / 1 h / Ambient temperature

5: 53 percent / DCC / CH₂Cl₂ / 0.5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrazine hydrate; magnesium; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00039a007

Reference yield:

: 23632-67-9
(S)-3-[3-(benzyloxycarbonyl)-5-oxooxazolidin-4-yl]propanoic acid

: 140677-47-0
(S)-3((benzyloxycarbonyl)amino)-2,3,4,5-tetrahydro-1H-pyrrolo<1,2-b><1,2>diazepin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / SOCl₂ / CH₂Cl₂; dimethylformamide / 2 h / Ambient temperature

2: 1) Mg / 1) THF, r.t., 30 min, 2) THF, -65 deg C, 1 h

3: 83 percent / 1 N NaOH / methanol / Ambient temperature

4: 23 percent / 20percent HCl / tetrahydrofuran / 0.25 h / 50 °C

5: 75 percent / N₂H₄*H₂O / methanol / 1 h / Ambient temperature

6: 53 percent / DCC / CH₂Cl₂ / 0.5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; thionyl chloride; hydrazine hydrate; magnesium; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00039a007