5-PHENYL-1H-PYRAZIN-2-ONE

Base Information

• Chemical Name: 5-PHENYL-1H-PYRAZIN-2-ONE
• CAS No.: 25844-72-8
• Molecular Formula: C10H8 N2 O
• Molecular Weight: 172.186
• Hs Code.: 2933990090
• Mol file: 25844-72-8.mol

Synonyms:Pyrazinol,5-phenyl- (8CI); 2-Hydroxy-5-phenylpyrazine; 5-Phenyl-2(1H)-pyrazinone;5-Phenyl-2-pyrazinol; 5-Phenylpyrazinol

Chemical Property of 5-PHENYL-1H-PYRAZIN-2-ONE

Chemical Property:

• Vapor Pressure: 1.39E-09mmHg at 25°C
• Refractive Index: 1.623
• Boiling Point: 473.4°Cat760mmHg
• Flash Point: 240.1°C
• PSA: 45.75000
• Density: 1.2g/cm³
• LogP: 1.43690

Purity/Quality:

97% ^*data from raw suppliers

5-Phenyl-1H-pyrazin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-PHENYL-1H-PYRAZIN-2-ONE

There total 12 articles about 5-PHENYL-1H-PYRAZIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-Chloro-5-phenyl-pyrazine (25844-73-9) → 2-hydroxy-5-phenylpyrazine (25844-72-8)

Guidance literature:

With acetylhydroxamic acid; potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 12h; Sealed tube;

DOI:10.1021/acs.orglett.6b00876

Reference yield: 73.0%

phenylglyoxal hydrate (1074-12-0) + glycinamide hydrochloride (1668-10-6) → 6-phenyl-3(2H)-pyridazinone (25844-72-8)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2006.10.041

Reference yield: 19.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-Chloro-5-phenyl-pyrazine (25844-73-9) → dimethyl-(5-phenyl-pyrazin-2-yl)-amine (67714-61-8) + 2-hydroxy-5-phenylpyrazine (25844-72-8)

Guidance literature:

With potassium hydroxide;

DOI:10.1055/s-1980-28915

upstream raw materials:

phenylglyoxal hydrate

glycinamide hydrochloride

acetophenone

phenylglyoxal monohydrate

Downstream raw materials:

2-Chloro-5-phenyl-pyrazine

1-(4-methoxybenzyl)-5-phenylpyrazin-2(1H)-one

1-methyl-5-phenylpyrazin-2(1H)-one

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