4'-<3-(benzylisopropylamino)-2-hydroxypropoxy>chloroacetanilide

Base Information

• Chemical Name: 4'-<3-(benzylisopropylamino)-2-hydroxypropoxy>chloroacetanilide
• CAS No.: 106163-10-4
• Molecular Formula: C₂₁H₂₇ClN₂O₃
• Molecular Weight: 390.91
• Mol file: 106163-10-4.mol

Synonyms:4'-<3-(benzylisopropylamino)-2-hydroxypropoxy>chloroacetanilide

Chemical Property of 4'-<3-(benzylisopropylamino)-2-hydroxypropoxy>chloroacetanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4'-<3-(benzylisopropylamino)-2-hydroxypropoxy>chloroacetanilide

There total 4 articles about 4'-<3-(benzylisopropylamino)-2-hydroxypropoxy>chloroacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4'-<3-(benzylisopropylamino)-2-hydroxypropoxy>aniline (6673-43-4) + chloroacetyl chloride (79-04-9) → 4'-<3-(benzylisopropylamino)-2-hydroxypropoxy>chloroacetanilide (106163-10-4)

Guidance literature:

With triethylamine; In diethyl ether; for 3h; Ambient temperature;

DOI:10.1021/jm00387a025

Reference yield:

1-(4-acetamidophenoxy)-2,3-epoxypropane (6597-75-7) → 4'-<3-(benzylisopropylamino)-2-hydroxypropoxy>chloroacetanilide (106163-10-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / methanol / 5 h / Heating

2: 82.5 percent / HCl / ethanol / 5 h / Heating

3: 70 percent / triethylamine / diethyl ether / 3 h / Ambient temperature

With hydrogenchloride; triethylamine; In methanol; diethyl ether; ethanol;

DOI:10.1021/jm00387a025

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) → 4'-<3-(benzylisopropylamino)-2-hydroxypropoxy>chloroacetanilide (106163-10-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 50 percent / NaOH / H₂O / 16 h / Ambient temperature

2: 89 percent / methanol / 5 h / Heating

3: 82.5 percent / HCl / ethanol / 5 h / Heating

4: 70 percent / triethylamine / diethyl ether / 3 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; triethylamine; In methanol; diethyl ether; ethanol; water;

DOI:10.1021/jm00387a025

upstream raw materials:

4'-<3-(benzylisopropylamino)-2-hydroxypropoxy>aniline

chloroacetyl chloride

1-(4-acetamidophenoxy)-2,3-epoxypropane

4-acetaminophenol

Downstream raw materials:

N-{4-[3-(Benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-2-[4-({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenylcarbamoyl}-methyl)-piperazin-1-yl]-acetamide

N-{4-[3-(Benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-2-{6-[({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenylcarbamoyl}-methyl)-amino]-hexylamino}-acetamide

N-{4-[3-(Benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-2-{8-[({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenylcarbamoyl}-methyl)-amino]-octylamino}-acetamide

N-{4-[3-(Benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenyl}-2-{4-[({4-[3-(benzyl-isopropyl-amino)-2-hydroxy-propoxy]-phenylcarbamoyl}-methyl)-amino]-butylamino}-acetamide